R Desbriere, V Vuaroqueaux, V Achard, S … - Obesity, 2006 - nature.com Objective: Data from rodents provide evidence for a causal role of 11
-hydroxysteroid dehydrogenase type 1 (11 -HSD-1) in the development of obesity
and its complications. In humans, 11 -HSD-1 is increased in subcutaneous ... Cited by 34 - Related articles - All 3 versions
EA Francischetti, VA Genelhu - International journal of clinical practice, 2007 - wolfdesign.it Hypertension is an important public health problem in different regions of the
world because of its high prevalence and concomitant risks of cardiovascular and
renal diseases(1). A recent analysis of worldwide data from different ... Cited by 33 - Related articles - View as HTML - BL Direct - All 7 versions
KM Starowicz, L Cristino, I Matias, R Capasso … - Obesity, 2008 - nature.com Objective: Reduction of cortisone to cortisol is mediated by 11 -hydroxysteroid
dehydrogenase type 1 (11 HSD1), a putative key enzyme in obesity-related
complications. Experimental studies suggest that adipokines, notably leptin ... Cited by 29 - Related articles - All 2 versions
- ►endojournals.org E Ferrannini, B Balkau, SW Coppack, JM … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Context: Insulin resistance (IR) and obesity, especially abdominal obesity, are
regarded as central pathophysiological features of a cluster of cardiovascular
risk factors (CVRFs), but their relative roles remain undefined. Moreover, ... Cited by 31 - Related articles - BL Direct - All 5 versions
BR Walker - Diabetic medicine, 2006 - pt.wkhealth.com Similarities between the metabolic syndrome and Cushing's syndrome, and
reversibility of the features of Cushing's syndrome, suggest that cortisol may
contribute to the pathophysiology of both conditions and that reducing ... Cited by 28 - Related articles - BL Direct - All 6 versions
BR Walker, R Andrew - Ann NY Acad Sci, 2006 - interscience.wiley.com Abstract: Activation of intracellular glucocorticoid receptors is determined not
only by the plasma concentrations of cortisol, under the influence of the
hypothalamic-pituitary-adrenal (HPA) axis, but also by 11HSD enzymes within ... Cited by 32 - Related articles - BL Direct - All 4 versions
JW Tomlinson, PM Stewart - Nature clinical practice. Endocrinology & metabolism, 2005 - ncbi.nlm.nih.gov The magnitude of the obesity and metabolic syndrome epidemic has heightened the
need for the development of new and effective treatments. Although circulating
cortisol concentrations are not elevated in obesity or in the metabolic ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►endojournals.org DJ Wake, NZM Homer, R Andrew, BR Walker - Journal of Clinical Endocrinology & Metabolism, 2006 - Endocrine Soc Context: Extraadrenal regeneration of cortisol by 11ß-hydroxysteroid
dehydrogenase type 1 (11HSD1) is increased after a mixed meal. It is unknown
which tissue is responsible and whether this reflects the complex ... Cited by 20 - Related articles - BL Direct - All 6 versions
SK Paulsen, SB Pedersen, S Fisker, B … - Obesity, 2007 - nature.com Objective: Pre-receptor amplification of glucocorticoids is, in part, determined
by the isoenzymes 11 -hydroxysteroid dehydrogenase (11 -HSD) type 1 and type 2,
interconverting inert cortisone and active cortisol. Increased tissue ... Cited by 19 - Related articles - All 2 versions
- ►endojournals.org P Marcolongo, S Piccirella, S Senesi, L … - Endocrinology, 2007 - Endocrine Soc 11ß-Hydroxysteroid dehydrogenase type 1, expressed mainly in the endoplasmic
reticulum of adipocytes and hepatocytes, plays an important role in the
prereceptorial activation of glucocorticoids. In liver endoplasmic ... Cited by 16 - Related articles - BL Direct - All 4 versions
