JA Bluestone, Q Tang - Current opinion in immunology, 2005 - Elsevier Any scientist opening up an immunology journal today will observe immediately that suppressor
T cells, renamed 'regulatory T cells' (Tregs) have become a central concept in the immunology
lexicon. Hundreds of Treg publications over the past few years have validated the ... Cited by 137 - Related articles - All 6 versions
Q Tang, JA Bluestone - Immunological reviews, 2006 - interscience.wiley.com Summary: Endowed with the ability to actively suppress an immune response, regulatory T cells
(Tregs) hold the promise of halting ongoing pathogenic autoimmunity and restoring self-tolerance
in patients suffering from autoimmune diseases. Through many in vitro and in vivo ... Cited by 117 - Related articles - BL Direct - All 5 versions
S You, B Leforban, C Garcia, JF Bach, JA … - Proceedings of the …, 2007 - National Acad Sciences Previous results have shown that CD4 + CD25 + regulatory T cells (Tregs) control autoimmunity
in a spontaneous model of type 1 diabetes, the nonobese diabetic (NOD) mouse. Moreover,
anti-CD3 reverses diabetes in this setting by promoting Tregs that function in a TGF-β- ... Cited by 70 - Related articles - BL Direct - All 7 versions
SM Kang, Q Tang, JA Bluestone - Am J Transplant, 2007 - pt.wkhealth.com The involvement of CD4 + CD25 + regulatory T cells (Treg) in general immune homeostasis
and protection from autoimmune syndromes is now well established. Similarly, there has been
increasing evidence for Treg involvement in allograft rejection and current ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►nih.gov Q Tang, JY Adams, C Penaranda, K Melli, E Piaggio, E … - Immunity, 2008 - Elsevier The dynamics of CD4 + effector T cells (Teff cells) and CD4 + Foxp3 + regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine
whether an imbalance of Treg cells and Teff cells contributes to the development of type 1 ... Cited by 55 - Related articles - All 7 versions
- ►diabetesjournals.org M Tritt, E Sgouroudis, E d'Hennezel, A Albanese, CA … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We show that the cellular frequency of Foxp3 + nT reg cells in primary and secondary
lymphoid tissues is stable and does not decline relative to type 1 diabetes–resistant mice. We
show that thymic and peripheral CD4 + CD25 + T-cells are fully functional in vivo. We also ... Cited by 33 - Related articles - BL Direct - All 5 versions
P Alard, JN Manirarora, SA Parnell, JL Hudkins, SL … - Diabetes, 2006 - Am Diabetes Assoc Various defects in antigen-presenting cells (APCs) and T-cells, including regulatory cells, have
been associated with type 1 diabetes development in NOD mice. CD4 + CD25 + regulatory cells
play a crucial role in controlling various autoimmune diseases, and a deficiency in their ... Cited by 31 - Related articles - BL Direct - All 6 versions
RJ Mellanby, D Thomas, JM Phillips, A Cooke - Immunology, 2007 - pubmedcentral.nih.gov The role of regulatory T cells (Tregs) in maintaining self tolerance has been intensively researched
and there is a growing consensus that a decline in Treg function is an important step towards
the development of autoimmune diseases, including diabetes. Although we show here ... Cited by 27 - Related articles - BL Direct - All 7 versions
KS Goudy, R Tisch - International reviews of immunology, 2005 - informahealthcare.com A major effort has been on-going to develop immunotherapies to prevent and/or treat type 1 diabetes
(T1D). This autoimmune disease is characterized by the selective loss of the insulin-producing
β cells via the cumulative effects of autoantigen-specific CD4 + and CD8 + T cells, ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org F Billiard, E Litvinova, D Saadoun, F Djelti, D … - The Journal of …, 2006 - Am Assoc Immnol Little is known about the in vivo conditions in which CD4 + CD25 + regulatory T cells (T reg )
exert their suppressive effect in nonlymphopenic mice. To this end, we analyzed T reg -mediated
suppression of expansion and cytokine production at different levels of Ag-specific CD4 + ... Cited by 25 - Related articles - BL Direct - All 4 versions
