- ►aspetjournals.org D Gong, J Lu, X Chen, SY Choong, S Zhang, YK Chan … - Molecular pharmacology, 2006 - ASPET Most patients with diabetes die from cardiac or arterial disease, for which there are limited
therapeutic options. Free Cu 2+ ions are strongly pro-oxidant, and chelatable-Cu II is increased in
the diabetic heart. We reported ... Cited by 10 - Related articles - All 6 versions
- ►aspetjournals.org J Lu, YK Chan, GD Gamble, SD Poppitt, AA Othman, … - Drug Metabolism and …, 2007 - ASPET Triethylenetetramine (TETA), a selective Cu II -chelator used in the treatment of Wilson's disease,
is now undergoing clinical trials for the treatment of heart failure in diabetes. Despite decades of
clinical use, knowledge of its ... Cited by 8 - Related articles - BL Direct - All 6 versions
DSH Bell - Cardiology Clinics, 2007 - Elsevier The number of patients with diabetes mellitus continues to rise in industrial societies owing mainly
to changes in lifestyle (excessive calorie and fat intake and decreased physical activity). It is
estimated that worldwide the number ... Cited by 5 - Related articles - All 14 versions
A HortResearch, N Zealand - PROTEOMICS - interscience.wiley.com Cardiac disease is the commonest cause of death amongst diabetic patients. Diabetic cardiomyopathy,
which has a poor prognosis, is characterized by left ventricular hypertrophy and impaired cardiac
function and mitochondrial damage ... Cited by 5 - Related articles - BL Direct
- ►clemson.edu [PDF] EE Battin, JL Brumaghim - Journal of Inorganic Biochemistry, 2008 - Elsevier Metals such as Cu I and Fe II generate hydroxyl radical ( OH) by reducing endogenous hydrogen
peroxide (H 2 O 2 ). Because antioxidants can ameliorate metal-mediated oxidative damage, we have
quantified the ability of ... Cited by 3 - Related articles - All 4 versions
TB Vaughan, DSH Bell - Heart Failure Clinics, 2006 - Elsevier Congestive heart failure is commonly associated with diabetes. In years past, it was assumed that
this association was largely based on the increased risk in the diabetic patient for ischemic heart
disease. More recently, it has ... Cited by 3 - Related articles - All 18 versions
GJS Cooper, AA Young, GD Gamble, CJ Occleshaw, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Cu(II)-selective chelation with trientine ameliorates cardiovascular and
renal disease in a model of diabetes in rats. Here, we tested the hypothesis that Cu(II)- selective
chelation might improve left ... Cited by 2 - Related articles - All 3 versions
GJ Cooper, AA Young, GD Gamble, CJ Occleshaw, … - Journal of Cardiac …, 2006 - Elsevier Introduction: Left-ventricular hypertrophy (LVH) and diastolic dysfunction frequently precede the
development of heart failure in diabetes mellitus, a condition characterised by chronic
hyperglycemia and cardiovascular ... Cited by 1 - Related articles
- ►nih.gov BA Berkowitz, M Gradianu, D Bissig, TS Kern, R … - … ophthalmology & visual …, 2009 - ARVO RESULTS. In WT mice, light adaptation reduced outer retinal manganese uptake compared with that in
dark adaptation; no effect on inner retinal uptake was found. In diabetic WT mice, intraretinal
manganese uptake became subnormal ... Cited by 1 - Related articles - All 5 versions
