- ►diabetesjournals.org K Susztak, AC Raff, M Schiffer, EP Böttinger - Diabetes, 2006 - Am Diabetes Assoc Diabetic nephropathy is the most common cause of end-stage renal disease in the
US Recent studies demonstrate that loss of podocytes is an early feature of
diabetic nephropathy that predicts its progressive course. Cause and ... Cited by 165 - Related articles - BL Direct - All 7 versions
- ►asnjournals.org M Ye, J Wysocki, J William, MJ Soler, I Cokic, … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Angiotensin-converting enzyme 2 (ACE2) expression has been shown to be altered
in renal tubules from diabetic mice. This study examined the localization of ACE
and ACE2 within the glomerulus of kidneys from control (db/m) and diabetic ... Cited by 60 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org S Shibata, M Nagase, S Yoshida, H Kawachi, T … - Hypertension, 2007 - Am Heart Assoc Accumulating evidence suggests that mineralocorticoid receptor blockade
effectively reduces proteinuria in hypertensive patients. However, the mechanism
of the antiproteinuric effect remains elusive. In this study, we ... Cited by 59 - Related articles - All 7 versions
- ►asnjournals.org C Ruster, G Wolf - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most
powerful maneuvers to slow progression of renal disease. Angiotensin II (AngII)
has emerged in the past decade as a multifunctional cytokine that exhibits ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org SH Sung, FN Ziyadeh, A Wang, PE Pyagay, … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol For investigation of how the vascular endothelial growth factor (VEGF) system
participates in the pathogenesis of diabetic kidney disease, type 2 diabetic
db/db and control db/m mice were treated intraperitoneally with vehicle or ... Cited by 44 - Related articles - BL Direct - All 5 versions
G Wolf, FN Ziyadeh - Nephron Physiol, 2007 - content.karger.com One of the earliest clinically detectable abnormalities in diabetic nephropathy
is microalbuminuria that eventually progresses to proteinuria. The degree of
proteinuria correlates with the progression of glomerulosclerosis and ... Cited by 41 - Related articles - BL Direct - All 5 versions
Y Ohshiro, RC Ma, Y Yasuda, J Hiraoka- … - Diabetes, 2006 - Am Diabetes Assoc Diabetes induces the activation of several protein kinase C (PKC) isoforms in
the renal glomeruli. We used PKC-β −/− mice to examine the action of PKC-β
isoforms in diabetes-induced oxidative stress and renal injury at 8 and 24 ... Cited by 38 - Related articles - BL Direct - All 6 versions
RC Wiggins - Kidney International, 2007 - nature.com Glomerular diseases encompass a broad array of clinicopathologically defined
syndromes which together account for 90% of end-stage kidney disease costing $20
billion per annum to treat in the United States alone. Recent insights have ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org C Szabó, A Biser, R Benkő, E Böttinger, K … - Diabetes, 2006 - Am Diabetes Assoc The activation of the poly(ADP-ribose) polymerase (PARP) plays an important role
in the pathophysiology of various diseases associated with oxidative stress. We
found increased amounts of poly(ADP) ribosylated proteins in diabetic ... Cited by 36 - Related articles - BL Direct - All 6 versions
MR Hayden, A Whaley-Connell, JR Sowers - American journal of nephrology, 2005 - content.karger.com Type 2 diabetes mellitus has reached epidemic proportions and diabetic
nephropathy is the leading cause of end-stage renal disease. The metabolic
syndrome constitutes a milieu conducive to tissue redox stress. This loss ... Cited by 31 - Related articles - All 6 versions
