E Bugianesi, AJ McCullough, G Marchesini… - Hepatology, 2005 - interscience.wiley.com Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty
liver disease (NAFLD), one of the most common causes of chronic liver disease in
Western countries. We review the definition of IR, the methods for the ... Cited by 169 - Related articles - BL Direct - All 3 versions
- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the
pathogenesis of T2DM are increasingly focused on disordered lipid ... Cited by 111 - Related articles - BL Direct - All 5 versions
- ►endojournals.org R Muniyappa, M Montagnani, KK Koh, MJ … - Endocrine reviews, 2007 - Endocrine Soc Insulin has important vascular actions to stimulate production of nitric oxide
from endothelium. This leads to capillary recruitment, vasodilation, increased
blood flow, and subsequent augmentation of glucose disposal in classical ... Cited by 99 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org H Ashrafian, MP Frenneaux, LH Opie - Circulation, 2007 - Am Heart Assoc Although neurohumoral antagonism has successfully reduced heart failure
morbidity and mortality, the residual disability and death rate remains
unacceptably high. Though abnormalities of myocardial metabolism are ... Cited by 65 - Related articles - All 5 versions
- ►shouxi.net M Bajaj, S Suraamornkul, A Romanelli, GW … - Diabetes, 2005 - Am Diabetes Assoc To investigate the effect of a sustained (7-day) decrease in plasma free fatty
acid (FFA) concentrations on insulin action and intramyocellular long-chain
fatty acyl-CoAs (LCFA-CoAs), we studied the effect of acipimox, a potent ... Cited by 52 - Related articles - BL Direct - All 5 versions
H Sell, D Dietze-Schroeder, J Eckel - Trends in Endocrinology & Metabolism, 2006 - Elsevier Insulin resistance in skeletal muscle is linked to an elevated adipose tissue
mass, as is found in obesity, but can also be observed in lipodystrophy, in
which adipose tissue is greatly reduced. Adipose tissue releases endocrine ... Cited by 47 - Related articles - All 3 versions
M Roden - International Journal of Obesity, 2005 - nature.com REL-DM exhibit defects in mitochondrial oxidation and phosphorylation. Increased
FFA availability results in accumulation of intramyocellular fatty acyl-CoA
(FA-CoA) inducing a series of alterations: (i) inhibition of insulin ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►shouxi.net JJ Senn - Journal of Biological Chemistry, 2006 - ASBMB Fatty acids can activate proinflammatory pathways leading to the development of
insulin resistance, but the mechanism is undiscovered. Toll like receptor 2
(TLR2) recognizes lipids, activates proinflammatory pathways, and is ... Cited by 40 - Related articles - BL Direct - All 8 versions
- ►ajcn.org MP Corcoran, S Lamon-Fava, RA Fielding - American Journal of Clinical Nutrition, 2007 - Am Soc Nutrition Mounting evidence indicates that elevated intramyocellular triacylglycerol
concentrations are associated with diminished insulin sensitivity in skeletal
muscle. This lipid accumulation is most likely due to enhanced fatty acid ... Cited by 36 - Related articles - BL Direct - All 12 versions
- ►ahajournals.org LH Opie - Circulation, 2007 - Am Heart Assoc The diagnosis of metabolic syndrome requires a tape measure or accurate eye;
fasting lipogram and plasma glucose measurements; and BP measurements. A-II
indicates angiotensin-II; FFA, free fatty acids; BP, blood pressure; FPG, ... Cited by 28 - Related articles - All 7 versions
