- ►diabetesjournals.org AV Matveyenko, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by defects in insulin secretion and action and
is preceded by impaired fasting glucose (IFG). The islet anatomy in IFG and type
2 diabetes reveals an ∼50 and 65% deficit in β-cell mass, with increased ... Cited by 39 - Related articles - BL Direct - All 4 versions
CD Man, RA Rizza, C Cobelli - IEEE Transactions on Biomedical Engineering, 2007 - ieeexplore.ieee.org Abstract A simulation model of the glucose-insulin system in the postprandial
state can be useful in several circumstances, including testing of glucose
sensors, insulin infusion algorithms and decision support systems for ... Cited by 35 - Related articles - BL Direct - All 2 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►shouxi.net AV Matveyenko, JD Veldhuis, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) often
coexist and as such represent a potent risk factor for subsequent development of
type 2 diabetes. β-Cell mass is ∼50% deficient in IFG and ∼65% ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►physiology.org C Cobelli, GM Toffolo, CD Man, M Campioni, P … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Assessment of insulin secretion in humans under physiological conditions has
been a challenge because of its complex interplay with insulin action and
hepatic insulin extraction. The possibility of simultaneously assessing ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►physiology.org … , DH Wasserman, OP McGuinness, IR Sweet, … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Islets in most species respond to increased glucose with biphasic insulin
secretion, marked by a sharp first-phase peak and a slowly rising second phase.
Mouse islets in vitro, however, lack a robust second phase. To date, this ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►geyseco.info [PDF] JJ Meier - Diabetologia, 2008 - Springer Abstract Beta cell deficiency underlies both type 1 and type 2 diabetes, and
restoration or replacement of beta cell function is therefore the logical
long-term solution to therapy. This review sets out to describe the defects ... Cited by 16 - Related articles - BL Direct - All 6 versions
AV Matveyenko, PC Butler - Diabetes Obes Metab, 2008 - interscience.wiley.com Regulation of blood glucose concentrations requires an adequate number of
β-cells that respond appropriately to blood glucose levels. β-Cell mass cannot
yet be measured in humans in vivo, necessitating autopsy studies, although ... Cited by 8 - Related articles - All 2 versions
JD Veldhuis, DM Keenan, SM Pincus - Endocrine Reviews, 2008 - Endocrine Soc Endocrine glands communicate with remote target cells via a mixture of
continuous and intermittent signal exchange. Continuous signaling allows slowly
varying control, whereas intermittency permits large rapid adjustments. The ... Cited by 7 - Related articles - All 3 versions
- ►physiology.org JJ Meier, JJ Holst, WE Schmidt, MA Nauck - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Changes in hepatic insulin clearance can occur after oral glucose or meal
ingestion. This has been attributed to the secretion and action of gastric
inhibitory polypeptide (GIP) and glucagon-like peptide (GLP)–1. Given the ... Cited by 7 - Related articles - BL Direct - All 5 versions
