PPM Rood, R Bottino, AN Balamurugan, Y Fan, DKC … - Pharmaceutical …, 2006 - Springer Received August 30, 2005; accepted October 13, 2005 Abstract. Type 1 diabetes (T1D) is an
autoimmune disease, the clinical onset of which most frequently presents in children and adolescents
who are genetically predisposed. T1D is characterized by specific insulin-producing beta ... Cited by 20 - Related articles - BL Direct - All 4 versions
M Li, S Peterson, D Husney, M Inaba, K Guo, … - Antioxidants & Redox …, 2007 - liebertonline.com T HE DIABETIC STATE IN NONOBESE DIABETIC (NOD) mice results from autoreactive T
cell–mediated autoimmune destruction of insulin-producing pancreatic beta cells due to defects
in both negative selection and peripheral tolerance in- duction (16, 39). Because diabetes ... Cited by 15 - Related articles - BL Direct - All 4 versions
A Kamagate, S Qu, G Perdomo, D Su, DH … - The Journal of …, 2008 - pubmedcentral.nih.gov Excessive production of triglyceride-rich VLDL is attributable to hypertriglyceridemia. VLDL production
is facilitated by microsomal triglyceride transfer protein (MTP) in a rate-limiting step that is regulated
by insulin. To characterize the underlying mechanism, we studied hepatic MTP regulation ... Cited by 16 - Related articles - BL Direct - All 7 versions
R Aikin, S Hanley, D Maysinger, M Lipsett, M … - Diabetologia, 2006 - Springer Page 1. ARTICLE Autocrine insulin action activates Akt and increases survival of
isolated human islets R. Aikin & S. Hanley & D. Maysinger & M. Lipsett & M. Castellarin
& S. Paraskevas & L. Rosenberg Received: 15 July 2006 ... Cited by 13 - Related articles - BL Direct - All 4 versions
RC Vasavada, L Wang, Y Fujinaka, KK Takane, TC … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— Diabetes results from a deficiency of functional β-cells. Previous studies have
identified hepatocyte growth factor (HGF) and parathyroid hormone–related protein (PTHrP)
as two potent β-cell mitogens. The objective of this study is to determine 1) whether HGF ... Cited by 7 - Related articles - BL Direct - All 3 versions
N Tellez, M Montolio, E Estil· les, J Escoriza, J Soler, E … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Interleukin-1 receptor antagonist (IL1RN, also known as IL1RA) is a
naturally occurring inhibitor of IL-1 action and its overproduction protects pancreatic islets from
the deleterious effects of IL-1β on beta cell replication, apoptosis and function. The aim of ... Cited by 5 - Related articles - BL Direct - All 4 versions
SB Widenmaier, AV Sampaio, TM Underhill, CHS … - Journal of Biological …, 2009 - ASBMB Therapeutics based on the actions of the incretin hormones, glucagon-like peptide-1
(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), have recently been introduced
for the treatment of type 2 diabetes mellitus. The serine/threonine kinase Akt is a major ... Cited by 4 - Related articles - All 3 versions
R Grempler, S Leicht, I Kischel, P Eickelmann, N … - FEBS letters, 2007 - Elsevier Inhibition of the lipid phosphatase SH2-domain containing inositol phosphatase 2 (SHIP2) in
L6-C10 muscle cells, in 3T3-L1 adipocytes and in the liver of db/db mice has been shown to
ameliorate insulin signal transduction and established SHIP2 as a negative regulator of ... Cited by 3 - Related articles - All 3 versions
N Fiaschi-Taesch, AF Stewart, A Garcia-Ocana - Cell biochemistry and …, 2007 - Springer Abstract Clinical studies have demonstrated that islet transplantation may be a useful procedure
to replace beta cell function in patients with Type 1 diabetes. Islet trans- plantation faces many
challenges, including complications associated with the procedure itself, the toxicity of ... Cited by 4 - Related articles - BL Direct - All 4 versions
Y Lai, I Drobinskaya, E Kolossov, C Chen, T Linn - Advanced drug delivery …, 2007 - Elsevier Progress in gene therapy has produced promising results that translate experimental research
into clinical treatment. Gene modification has been extensively employed in cell
transplantation. The main barrier is an effective gene delivery system. Several viral ... Cited by 3 - Related articles - All 4 versions
