- ►nih.gov YC Long, JR Zierath - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates
glucose uptake and lipid oxidation to produce energy, while turning off ... Cited by 164 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org P Plomgaard, K Bouzakri, R Krogh-Madsen, B … - Diabetes, 2005 - Am Diabetes Assoc Most lifestyle-related chronic diseases are characterized by low-grade systemic
inflammation and insulin resistance. Excessive tumor necrosis factor-α (TNF-α)
concentrations have been implicated in the development of insulin ... Cited by 102 - Related articles - BL Direct - All 4 versions
- ►shouxi.net HF Kramer, CA Witczak, N Fujii, N Jessen, … - Diabetes, 2006 - Am Diabetes Assoc Insulin and contraction increase GLUT4 translocation in skeletal muscle via
distinct signaling mechanisms. Akt substrate of 160 kDa (AS160) mediates
insulin-stimulated GLUT4 translocation in L6 myotubes, presumably through ... Cited by 85 - Related articles - BL Direct - All 6 versions
L Chang, SH Chiang, AR Saltiel - Molecular Medicine, 2004 - pubmedcentral.nih.gov Gaps remain in our understanding of the precise molecular mechanisms by which
insulin regulates glucose uptake in fat and muscle cells. Recent evidence
suggests that insulin action involves multiple pathways, each ... Cited by 85 - Related articles - BL Direct - All 7 versions
- ►shouxi.net JT Treebak, S Glund, A Deshmukh, DK Klein, … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a heterotrimeric protein that regulates
glucose transport mediated by cellular stress or pharmacological agonists such
as 5-aminoimidazole-4-carboxamide 1 β-d-ribonucleoside (AICAR). AS160, a ... Cited by 82 - Related articles - BL Direct - All 7 versions
- ►physiology.org FSL Thong, CB Dugani, A Klip - Physiology, 2005 - cat.inist.fr Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues
is achieved by accelerating glucose transporter GLUT 4 exocytosis from
intracellular compartments to the plasma membrane and minimally reducingits ... Cited by 79 - Related articles - BL Direct - All 4 versions
- ►uc.pt [PDF] RT Watson, JE Pessin - Trends in biochemical sciences, 2006 - Elsevier Upon binding and activating its cell-surface receptor, insulin triggers
signaling cascades that regulate many cellular processes. Regarding glucose
homeostasis, insulin suppresses hepatic glucose production and increases ... Cited by 69 - Related articles - All 8 versions
B Dummler, BA Hemmings - Biochemical Society Transactions, 2007 - biochemsoctrans.cn Abstract PKB (protein kinase B, also known as Akt) is a serine/threonine protein
kinase that is important in various signalling cascades and acts as a major
signal transducer downstream of activated phosphoinositide 3-kinase. There ... Cited by 49 - Related articles - View as HTML - BL Direct - All 5 versions
- ►shouxi.net A Deshmukh, VG Coffey, Z Zhong, AV Chibalin … - Diabetes, 2006 - Am Diabetes Assoc Skeletal muscle contraction stimulates multiple signaling cascades that govern a
variety of metabolic and transcriptional events. Akt/protein kinase B regulates
metabolism and growth/muscle hypertrophy, but contraction effects on this ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►shouxi.net FSL Thong, PJ Bilan, A Klip - Diabetes, 2007 - Am Diabetes Assoc Insulin-dependent phosphorylation of Akt target AS160 is required for GLUT4
translocation. Insulin and platelet-derived growth factor (PDGF) (Akt
activators) or activation of conventional/novel (c/n) protein kinase C ... Cited by 43 - Related articles - BL Direct - All 5 versions
