- ►nih.gov B Bisikirska, J Colgan, J Luban, JA Bluestone … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Modified anti-CD3 mAbs are emerging as a possible means of inducing immunologic
tolerance in settings including transplantation and autoimmunity such as in type
1 diabetes. In a trial of a modified anti-CD3 mAb [hOKT3γ1(Ala-Ala)] in ... Cited by 136 - Related articles - BL Direct - All 12 versions
Q Tang, JA Bluestone - Immunological reviews, 2006 - interscience.wiley.com Summary: Endowed with the ability to actively suppress an immune response,
regulatory T cells (Tregs) hold the promise of halting ongoing pathogenic
autoimmunity and restoring self-tolerance in patients suffering from ... Cited by 116 - Related articles - BL Direct - All 5 versions
- ►nih.gov T Nir, DA Melton, Y Dor - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The mechanisms that regulate pancreatic β cell mass are poorly understood.
While autoimmune and pharmacological destruction of insulin-producing β cells
is often irreversible, adult β cell mass does fluctuate in response to ... Cited by 99 - Related articles - BL Direct - All 8 versions
- ►cell.com LKM Shoda, DL Young, S Ramanujan, CC … - Immunity, 2005 - Elsevier Type 1 diabetes (T1D) animal models such as the nonobese diabetic (NOD) mouse
have improved our understanding of disease pathophysiology, but many candidate
therapeutics identified therein have failed to prevent/cure human disease. ... Cited by 94 - Related articles - All 6 versions
- ►nih.gov D Bresson, L Togher, E Rodrigo, Y Chen, JA … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Safe induction of autoantigen-specific long-term tolerance is the “holy
grail” for the treatment of autoimmune diseases. In animal models of type 1
diabetes, oral or in immunization with islet antigens induces Tregs that ... Cited by 90 - Related articles - BL Direct - All 12 versions
S You, B Leforban, C Garcia, JF Bach, JA … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Previous results have shown that CD4 + CD25 + regulatory T cells (Tregs) control
autoimmunity in a spontaneous model of type 1 diabetes, the nonobese diabetic
(NOD) mouse. Moreover, anti-CD3 reverses diabetes in this setting by ... Cited by 69 - Related articles - BL Direct - All 7 versions
- ►ecmaj.com KM Gillespie - Canadian Medical Association Journal, 2006 - ecmaj.com Type 1 diabetes results from the autoimmune destruction of insulin-producing ß
cells in the pancreas. Genetic and, as yet undefined, environmental factors act
together to precipitate the disease. The excess mortality associated with ... Cited by 60 - Related articles - BL Direct - All 13 versions
H Ochi, M Abraham, H Ishikawa, D Frenkel, K … - Nat Med, 2006 - 140.116.93.232 A major goal of immunotherapy for autoimmune diseases and transplantation is
induction of regulatory T cells that mediate immunologic tolerance. The mucosal
immune system is unique, as tolerance is preferentially induced after ... Cited by 58 - Related articles - View as HTML - BL Direct - All 9 versions
LS Taams, DB Palmer, AN Akbar, DS … - Immunology, 2006 - pubmedcentral.nih.gov Regulatory T cells are proposed to play a central role in the maintenance of
immunological tolerance in the periphery, and studies in many animal models
demonstrate their capacity to inhibit inflammatory pathologies in vivo. At ... Cited by 46 - Related articles - BL Direct - All 5 versions
T Staeva-Vieira, M Peakman, M Von Herrath - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov Type 1 diabetes (T1D) is often considered the prototype organ-specific
autoimmune disease in clinical immunology circles. The key disease features −
precise destruction of a single endocrine cell type occurring on a distinct ... Cited by 46 - Related articles - BL Direct - All 5 versions
