- ►onlinejacc.org L Cai, Y Wang, G Zhou, T Chen, Y Song, X Li, YJ … - Journal of the American …, 2006 - Elsevier Our previous study showed that cardiac apoptosis as a major early cellular response to diabetes
is induced by hyperglycemia-derived oxidative stress that activates a mitochondrial cytochrome
c-mediated caspase-3 activation pathway. Metallothionein (MT) as a potent antioxidant ... Cited by 51 - Related articles - BL Direct - All 20 versions
- ►fasebj.org X Yang, TA Doser, CX Fang, JM Nunn, R Janardhanan, … - The FASEB Journal, 2006 - FASEB THE PREVALENCE OF HEART FAILURE is significantly higher in the elderly compared with
the middle-aged or young population, indicating that aging or senescence per se plays an important
role in cardiac dysfunction (1) . Ample evidence has implicated free radical accumulation ... Cited by 44 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org J Wang, Y Song, L Elsherif, Z Song, G Zhou, SD … - Circulation, 2006 - Am Heart Assoc Methods and Results— Diabetes was induced in mice (C57BL/6J strain) by a single injection
of streptozotocin. Half were supplemented intraperitoneally with zinc sulfate (5 mg/kg) every
other day for 3 months. After zinc supplementation, mice were maintained for 3 more ... Cited by 44 - Related articles - All 10 versions
- ►nih.gov P Pacher, C Szabó - Current opinion in pharmacology, 2006 - Elsevier Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, lead to increased
polyol pathway flux, activation of protein kinase C and accelerated non-enzymatic formation
of advanced glycation end products. Many of these pathways become activated in ... Cited by 43 - Related articles - All 5 versions
- ►ebmonline.org YJ Kang - Experimental Biology and Medicine, 2006 - SEBM The biologic function of metallothionein (MT) has been a perplexing topic ever since the discovery
of this protein. Many studies have suggested that MT plays a role in the homeostasis of essential
metals such as zinc and copper, detoxification of toxic metals such as cadmium, and ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►uwyo.edu [PDF] CX Fang, F Dong, BH Ren, PN Epstein, J Ren - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Insulin resistance is concom- itant with metabolic syndrome, oxidative
stress and cardiac contractile dysfunction. However, the causal relationship between oxidative
stress and cardiac dysfunction is un- known. This study was designed to determine the ... Cited by 28 - Related articles - BL Direct - All 6 versions
- ►uwyo.edu [PDF] LE Wold, AF Ceylan-Isik, CX Fang, X Yang, SY Li, … - Free Radical Biology and …, 2006 - Elsevier Diabetic cardiomyopathy contributes to high morbidity and mortality in diabetic populations. It
is manifested by compromised ventricular contraction and prolonged relaxation attributable to
multiple causative factors including oxidative stress. This study was designed to examine ... Cited by 23 - Related articles - All 5 versions
L Cai - Free Radical Biology and Medicine, 2006 - Elsevier Diabetic cardiomyopathy has become a major contributor to the increased mortality of diabetic
patients. Although the development and progression of diabetic cardiomyopathy are considered
to be associated with diabetes-derived oxidative stress, the precise mechanisms for and ... Cited by 22 - Related articles - All 6 versions
- ►hoshi.ac.jp [PDF] T Matsumoto, E Noguchi, T Kobayashi, K Kamata - Free Radical Biology and …, 2007 - Elsevier The objectives of this study were to determine the effects of chronic treatment with
pioglitazone, a peroxisome proliferator-activated receptor γ agonist, on the impaired
endothelium-dependent relaxation seen in aortas from established streptozotocin (STZ)- ... Cited by 22 - Related articles - All 5 versions
CX Fang, TA Doser, X Yang, N Sreejayan, J Ren - Aging Cell, 2006 - uwyo.edu Aging is often accompanied by reduced insulin sensitivity and cardiac dysfunction. However,
the causal relationship between the two remains poorly understood. This study was designed
to determine the impact of cardiac-specific overexpression of antioxidant metallothionein ( ... Cited by 16 - Related articles - View as HTML - All 4 versions
