- ►nih.gov DB Savage, CS Choi, VT Samuel, ZX Liu, D … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Hepatic steatosis is a core feature of the metabolic syndrome and type 2
diabetes and leads to hepatic insulin resistance. Malonyl-CoA, generated by
acetyl-CoA carboxylases 1 and 2 (Acc1 and Acc2), is a key regulator of both ... Cited by 96 - Related articles - BL Direct - All 13 versions
- ►nih.gov S Davis, B Lollo, S Freier, C Esau - Nucleic acids research, 2006 - Oxford Univ Press MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target
mRNAs post-transcriptionally by binding with imperfect complementarity in the
3'-untranslated region (3'-UTR) and inhibiting translation or RNA ... Cited by 72 - Related articles - BL Direct - All 11 versions
CS Choi, DB Savage, A Kulkarni, XX Yu, ZX … - Journal of Biological Chemistry, 2007 - ASBMB Nonalcoholic fatty liver disease (NAFLD) is a major contributing factor to
hepatic insulin resistance in type 2 diabetes. Diacylglycerol acyltransferase
(Dgat), of which there are two isoforms (Dgat1 and Dgat2), catalyzes the ... Cited by 48 - Related articles - All 8 versions
AM Stranahan, TV Arumugam, RG Cutler, K … - Nature - basicmed.med.ncku.edu.tw Many organ systems are adversely affected by diabetes, including the brain,
which undergoes changes that may increase the risk of cognitive decline.
Although diabetes influences the hypothalamic-pituitary-adrenal axis, the ... Cited by 42 - Related articles - View as HTML - BL Direct - All 6 versions
A Navas-Acien, EK Silbergeld, RA Streeter, JM … - Environmental health perspectives, 2006 - pubmedcentral.nih.gov Type 2 diabetes mellitus is a metabolic disorder characterized by hyperglycemia,
insulin resis- tance in peripheral tissues, and altered insulin secretory
capacity of pancreatic β-cells. Type 2 diabetes accounts for 90–95% of ... Cited by 36 - Related articles - BL Direct - All 23 versions
A Lonardo, C Carani, N Carulli, P Loria - Journal of hepatology, 2006 - Elsevier In 1980, Ludwig named nonalcoholic steatohepatitis (NASH) what we now consider
to be one of the manifestations of the broader nonalcoholic fatty liver disease
(NAFLD) spectrum. He described 20 patients whose liver biopsy specimens ... Cited by 28 - Related articles - All 11 versions
CC Esau - Methods, 2008 - Elsevier MicroRNAs are a recently discovered class of endogenously-encoded,
post-transcriptional gene regulators. They inhibit gene expression by binding in
the 3′UTR of target mRNAs with imperfect complementarity and preventing ... Cited by 19 - Related articles - All 2 versions
- ►endojournals.org Y Liu, C Yan, Y Wang, Y Nakagawa, N Nerio, … - Endocrinology, 2006 - Endocrine Soc The glucocorticoid receptor (GR) is a crucial target gene for
glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to
the development of type 2 diabetes. The liver X receptors (LXRs) are ... Cited by 15 - Related articles - BL Direct - All 4 versions
BR Walker - Proceedings of the Nutrition Society, 2007 - Cambridge Univ Press The major glucocorticoid in man, cortisol, plays important roles in regulating
fuel metabolism, energy partitioning and body fat distribution. In addition to
the control of cortisol levels in blood by the hypothalamic–pituitary– ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►jlr.org EA Hanniman, G Lambert, Y Inoue, FJ … - The Journal of Lipid Research, 2006 - ASBMB Apolipoprotein A-IV (apoA-IV) is a 46 kDa glycoprotein that associates with
triglyceride-rich and high density lipoproteins. Blood levels of apoA-IV
generally correlate with triglyceride levels and are increased in diabetic ... Cited by 8 - Related articles - BL Direct - All 5 versions
