R Saxena, L Gianniny, NP Burtt, V Lyssenko, C … - Diabetes, 2006 - Am Diabetes Assoc Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased
risk of type 2 diabetes in samples from Iceland, Denmark, and the US We genotyped 13 single
nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based ... Cited by 160 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org HN Lyon, JC Florez, T Bersaglieri, R Saxena, W … - Diabetes, 2006 - Am Diabetes Assoc The common missense single nucleotide polymorphism (SNP) K121Q in the ectoenzyme nucleotide
pyrophosphate phosphodiesterase (ENPP1) gene has recently been associated with type 2
diabetes in Italian, US, and South-Asian populations. A three-SNP haplotype, including ... Cited by 48 - Related articles - BL Direct - All 7 versions
- ►nih.gov MI McCarthy, E Zeggini - Current Diabetes Reports, 2006 - Springer Introduction The growing prevalence of type 2 diabetes and obesity in societies worldwide is
widely recognized as among the greatest threats to global health in the coming century [1].
Nevertheless, we remain far from a comprehensive understanding of the molecular ... Cited by 31 - Related articles - BL Direct - All 8 versions
JM Chen, C Ferec, DN Cooper - Human genetics, 2006 - Springer Abstract In an attempt both to catalogue 3¢ regulatory region (3¢ RR)-mediated disease and
to improve our understanding of the structure and function of the 3¢ RR, we have performed
a systematic analysis of disease- associated variants in the 3¢ RRs of human protein- ... Cited by 29 - Related articles - BL Direct - All 4 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the pancreatic beta
cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and hormone-like
molecules from adipocytes, hepatic glucose production, and likely the central nervous ... Cited by 25 - Related articles - All 3 versions
S Koren, IG Fantus - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier The global epidemic of obesity and type-2 diabetes mellitus (T2DM) has highlighted the need
for new therapeutic approaches. The association of insulin resistance with these disorders and
the knowledge that insulin receptor signaling is mediated by tyrosine (Tyr) ... Cited by 15 - Related articles - All 16 versions
MA Karim, X Wang, TC Hale, SC Elbein - BMC Medical Genetics, 2005 - biomedcentral.com We identified 8 variants in the two populations, including a 3 bp insertion in exon 2
(InsCCG243) in African Americans that resulted in an in-frame proline insertion in the transactivation
domain. No variant was associated with T2DM in Caucasians, but polymorphisms at ... Cited by 12 - Related articles - Cached - All 8 versions
- ►diabetesjournals.org SK Das, WS Chu, TC Hale, X Wang, RL Craig, H Wang, … - Diabetes, 2006 - Am Diabetes Assoc Linkage of type 2 diabetes to chromosome 1q21-q23 is well replicated across populations. In
an initial 50-kb marker map (580 markers) across the linked region, one of the two strongest
associations observed in Utah Caucasians was at marker rs1503814 (P < 0.00001 in ... Cited by 12 - Related articles - BL Direct - All 6 versions
- ►shouxi.net MW Sun, JY Lee, PIW de Bakker, NP Burtt, P Almgren, … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a key molecular regulator of cellular metabolism, and
its activity is induced by both metformin and thiazolidinedione antidiabetic medications. It has
therefore been proposed both as a putative agent in the pathophysiology of type 2 ... Cited by 11 - Related articles - BL Direct - All 6 versions
