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Scholar Results 1 - 10 of about 25 citing Basu: Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as.... (0.18 sec) 

Inhibition of fructose 1, 6-bisphosphatase reduces excessive endogenous glucose production …


PD van Poelje, SC Potter, VC Chandramouli, … - Diabetes, 2006 - Am Diabetes Assoc
Gluconeogenesis is increased in type 2 diabetes and contributes significantly to
fasting and postprandial hyperglycemia. We recently reported the discovery of
the first potent and selective inhibitors of fructose 1,6-bisphosphatase ...
Cited by 16 - Related articles - BL Direct - All 5 versions

Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin …


R Basu, P Shah, A Basu, B Norby, B Dicke, … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—Glucose was clamped before and after therapy at ∼5 mmol/l, insulin
raised to ∼180 pmol/l, C-peptide suppressed with somatostatin, glucagon
replaced at ∼75 pg/ml, and glycerol maintained at ∼200 mmol/l to ensure ...
Cited by 10 - Related articles - BL Direct - All 8 versions

18F-FDG assessment of glucose disposal and production rates during fasting and insulin …

- snmjournals.org
P Iozzo, A Gastaldelli, MJ Jarvisalo, J Kiss, … - Journal of Nuclear Medicine, 2006 - Soc Nuclear Med
The glucose analog 18 F-FDG is commonly used to quantify regional glucose uptake
in vivo. The aim of this study was to test whether the analysis of plasma 18
F-FDG kinetics could be used to estimate endogenous glucose production ...
Cited by 9 - Related articles - BL Direct - All 3 versions

Contribution of Hepatic and Extrahepatic Insulin Resistance to the Pathogenesis of …


G Bock, E Chittilapilly, R Basu, G Toffolo, C … - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—Despite higher (P < 0.001) insulin and C-peptide concentrations and
visceral fat (P < 0.05), fasting EGP and glucose disposal did not differ between
IFG and NFG subjects, implying hepatic and extrahepatic insulin resistance. ...
Cited by 7 - Related articles - BL Direct - All 5 versions

Diurnal rhythm in endogenous glucose production is a major contributor to fasting …

- edulife.com.br [PDF] 
J Radziuk, S Pye - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis: An increase in endogenous glucose production (EGP) is
a major contributor to fasting morning hyperglycaemia in type 2 diabetes. This
increase is dissipated with fasting, later in the day. To understand its ...
Cited by 5 - Related articles - BL Direct - All 5 versions

Sources of endogenous glucose production in the Goto–Kakizaki diabetic rat


CM Sena, C Barosa, E Nunes, R Seica, JG … - Diabetes and Metabolism, 2007 - Elsevier
Plasma glucose, insulin and glucose tolerance were quantified in diabetic
Goto–Kakizaki (GK) rats (342 ± 45 g, n = 5) and compared with weight-matched
non-diabetic Wistars (307 ± 30 g, n = 8). Compared to Wistars, GK rats had ...
Cited by 4 - Related articles - BL Direct - All 2 versions

Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the …


FQ Nuttall, A Ngo, MC Gannon - Diabetes/Metabolism Reviews - interscience.wiley.com
It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ...
Cited by 3 - Related articles - All 3 versions

Glucagon receptor antagonism improves islet function in mice with insulin resistance induced …


MS Winzell, CL Brand, N Wierup, UG … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis Increased glucagon secretion predicts dete- rioration
of glucose tolerance, and high glucagon levels contribute to hyperglycaemia in
type 2 diabetes. Inhibition of glucagon action may therefore be a potential ...
Cited by 2 - Related articles - BL Direct - All 6 versions

Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 …

- 192.35.79.232 [PDF] 
JP Kirwan, TPJ Solomon, DM Wojta, MA … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc
The objectives of this study were to determine whether 1) the improvement in
insulin action induced by short-term exercise training in patients with type 2
diabetes is due to an improvement in insulin sensitivity, an improvement in ...
Cited by 2 - Related articles - All 7 versions

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose …


H Yan, W Gu, J Yang, V Bi, Y Shen, E Lee, KA … - Journal of Pharmacology and Experimental …, 2009 - ASPET
Antagonizing the glucagon signaling pathway represents an attractive therapeutic
approach for reducing excess hepatic glucose production in patients with type 2
diabetes. Despite extensive efforts, there is currently no human ...
Cited by 2 - Related articles - All 4 versions


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