B Guigas, L Bertrand, N Taleux, M Foretz, N … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) controls glucose uptake and glycolysis in muscle. Little
is known about its role in liver glucose uptake, which is controlled by glucokinase. We report
here that 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), metformin, ... Cited by 45 - Related articles - BL Direct - All 6 versions
L Agius - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier Type-2 diabetes is associated with impaired glucose clearance by the liver in the postprandial
state, and with elevated glucose production in the post-absorptive state. New targets within the
liver are currently being investigated for development of antihyperglycaemic drugs for ... Cited by 17 - Related articles - All 17 versions
T Koeck, D Stuehr, K Aulak - Biochemical Society Transactions, 2005 - bst.portlandpress.com The conditions of the cellular microenvironment in complex multicellular organisms fluctuate,
enforcing permanent adaptation of cells at multiple regulatory levels. Covalent post-translational
modifications of proteins provide the short-term response tools for cellular adjustment and ... Cited by 13 - Related articles - Cached - BL Direct - All 11 versions
CM García-Herrero, M Galan, O Vincent, B Flandez, M … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Glucokinase (GCK) acts as a glucose sensor in the pancreatic beta
cell and regulates insulin secretion. In the gene encoding GCK the heterozygous mutations that
result in enzyme inactivation cause MODY2. Functional studies of naturally occurring ... Cited by 13 - Related articles - BL Direct - All 5 versions
L Harndahl, D Schmoll, AW Herling, L Agius - FEBS JOURNAL, 2006 - interscience.wiley.com Pharmacological activation or overexpression of glucokinase in hepatocytes stimulates glucose
phosphorylation, glycolysis and glycogen synthesis. We used an inhibitor of glucose 6-phosphate
(Glc6P) hydrolysis, namely the chlorogenic derivative, 1-[2-(4-chloro-phenyl)- ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►ncl.ac.uk [PDF] C Arden, S Baltrusch, L Agius - FEBS letters, 2006 - Elsevier The association of glucokinase with liver mitochondria has been reported [Danial et al.
(2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and
apoptosis. Nature 424, 952–956]. We confirmed association of glucokinase ... Cited by 10 - Related articles - All 12 versions
M Combettes, C Kargar - Therapie, 2007 - edpsciences. org Abstract – Type 2 diabetes is an endocrine/metabolic disease characterized by
hyperglycemia. It is now well established that insulin resistance and pancreatic β-cell
dysfunction/failure are the two major components of the physiopathology of the disease. ... Cited by 10 - Related articles - All 3 versions
L Agius - Biochemical Journal, 2008 - eng.auburn.edu Conversion of glucose into glycogen is a major pathway that contributes to the removal of glucose
from the portal vein by the liver in the postprandial state. It is regulated in part by the increase
in blood-glucose concentration in the portal vein, which activates glucokinase, the first ... Cited by 10 - Related articles - View as HTML - All 5 versions
J Gancedo - FEMS Microbiology Reviews, 2008 - interscience.wiley.com In the presence of glucose, yeast undergoes an important remodelling of its metabolism. There
are changes in the concentration of intracellular metabolites and in the stability of proteins and
mRNAs; modifications occur in the activity of enzymes as well as in the rate of ... Cited by 11 - Related articles - All 5 versions
- ►endojournals.org S Baltrusch, S Langer, L Massa, M Tiedge, S Lenzen - Endocrinology, 2006 - Endocrine Soc The glucose sensor enzyme glucokinase plays a pivotal role in the regulation of glucose-induced
insulin secretion in pancreatic ß-cells. Activation of glucokinase represents a promising concept
for the treatment of type 2 diabetes. Therefore, we analyzed the glucokinase activation ... Cited by 8 - Related articles - BL Direct - All 4 versions
