J Janke, S Engeli, M Boschmann, F Adams, J Böhnke, … - Diabetes, 2006 - Am Diabetes Assoc Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose
metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been
validated in humans. RBP4 was highly expressed in isolated mature human adipocytes ... Cited by 146 - Related articles - BL Direct - All 6 versions
PD Taylor, L Poston - Experimental Physiology, 2007 - Physiological Soc Converging lines of evidence from epidemiological studies and animal models now indicate
that the origins of obesity and related metabolic disorders lie not only in the interaction between
genes and traditional adult risk factors, such as unbalanced diet and physical inactivity, ... Cited by 72 - Related articles - BL Direct - All 9 versions
- ►ahajournals.org H Katagiri, T Yamada, Y Oka - Circulation research, 2007 - Am Heart Assoc Obesity, a major healthcare issue, is associated with significant cardiovascular morbidities, including
hypertension and atherosclerosis. Numerous intensive studies conducted this decade have revealed
that adipose tissue is a major endocrine organ that secretes a variety of bioactive ... Cited by 52 - Related articles - All 6 versions
WG Haynes - Experimental physiology, 2005 - Physiological Soc Obesity in humans causes hypertension, myocardial hypertrophy and coronary
atherosclerosis, and increased cardiovascular morbidity and mortality that is thought to be related
to sympathetic overactivity. Leptin is an adipocyte-derived hormone that acts in the ... Cited by 47 - Related articles - BL Direct - All 19 versions
J Beltowski - Journal of hypertension, 2006 - journals.lww.com Leptin is a 16-kDa protein secreted by white adipose tissue that is primarily involved in the regulation
of food intake and energy expenditure. Plasma leptin concentration is proportional to the amount
of adipose tissue and is markedly increased in obese individuals. Recent studies suggest ... Cited by 42 - Related articles - BL Direct - All 8 versions
AM Samuelsson, PA Matthews, M Argenton, MR … - Hypertension, 2008 - Am Heart Assoc Maternal obesity is increasingly prevalent and may affect the long-term health of the child. We
investigated the effects of maternal diet-induced obesity in mice on offspring metabolic and cardiovascular
function. Female C57BL/6J mice were fed either a standard chow (3% fat, 7% sugar) or a ... Cited by 43 - Related articles - All 6 versions
- ►leptiprorx.com [PDF] MLG Correia, K Rahmouni - Diabetes, Obesity & Metabolism, 2006 - pt.wkhealth.com Results: Hyperleptinaemia is common in obesity and reflects increased adiposity and leptin
resistance. Nevertheless, leptin resistance may not be complete as several actions of leptin,
such as cardiovascular sympatho-activation, might be preserved in obese subjects known ... Cited by 43 - Related articles - BL Direct - All 14 versions
GR Hajer, TW van Haeften, FLJ Visseren - European Heart Journal, 2008 - Eur Soc Cardiology The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk
factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes
mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as ... Cited by 34 - Related articles - All 4 versions
PE Bravo, S Morse, DM Borne, EA … - Vascular Health and …, 2006 - pubmedcentral.nih.gov Leptin, a peptide discovered more than 10 years ago, decreases food intake and increases sympathetic
nerve activity to both thermogenic and nonthermogenic tissue. Leptin was initially believed to
be an anti-obesity hormone, owing to its metabolic effects. However, obese individuals, ... Cited by 30 - Related articles - BL Direct - All 7 versions
