- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►endojournals.org EC Kaizer, CL Glaser, D Chaussabel, J … - Journal of Clinical …, 2007 - Endocrine Soc Results: Microarray analysis identified 282 genes differing in expression between newly diagnosed
T1D patients and controls at a false discovery rate of 0.05. Changes in expression of IL1B, early
growth response gene 3, and prostaglandin-endoperoxide synthase 2 resolved within 4 ... Cited by 18 - Related articles - BL Direct - All 3 versions
S Lenzen - Biochemical Society Transactions, 2008 - biochemsoctrans.org Antioxidative defence mechanisms of pancreatic β-cells are particularly weak and can be overwhelmed
by redox imbalance arising from overproduction of reactive oxygen and reactive nitrogen
species. The consequences of this redox imbalance are lipid peroxidation, oxidation of ... Cited by 16 - Related articles - Cached - BL Direct - All 6 versions
A Jörns, KJ Rath, O Bock, S Lenzen - Diabetologia, 2006 - Springer Abstract Aims/hypothesis It has recently been proposed that IL-1β may be responsible for beta
cell death in type 2 diabetes mellitus. Major support for this assumption was derived from experiments
in the gerbil Psammomys obesus (sand rat), a model for nutritionally induced non-insulin- ... Cited by 11 - Related articles - All 4 versions
CE Mathews - Pediatric diabetes, 2005 - ncbi.nlm.nih.gov 1: Pediatr Diabetes. 2005 Sep;6(3):165-77. Utility of murine models for the study of
spontaneous autoimmune type 1 diabetes. Mathews CE. Department of Pediatrics, The
University of Pittsburgh, Pittsburgh, PA 15213, USA. cem65@pitt.edu. ... Cited by 9 - Related articles - BL Direct - All 3 versions
BO ROEP - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2007 - interscience.wiley.com Abstract : Despite decades of research using various animal models for type 1 diabetes, we are
still struggling to define the initiating autoantigens, the precise mechanisms of β cell
destruction, and suitable immune-based interventions to prevent or treat human diabetes. ... Cited by 9 - Related articles - BL Direct - All 5 versions
A Willcox, SJ Richardson, AJ Bone, AK Foulis, … - Clin Exp …, 2009 - interscience.wiley.com The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because
of the limited availability of appropriate samples, but we now report a detailed study charting
the evolution of insulitis in human T1D. Pancreas samples removed post-mortem from 29 ... Cited by 6 - Related articles - All 3 versions
H Ortsater, P Bergsten - Expert Review of Proteomics, 2006 - ingentaconnect.com The insulin-producing β cell in the islet of Langerhans is central in glucose homeostasis. Its dysfunction
is part of the pathogenesis of both Type 1 and 2 diabetes mellitus. In both forms of the
disease, there is a cytotoxic component either induced by cytokines, as in Type 1 ... Cited by 5 - Related articles - BL Direct - All 4 versions
- ►critcaremed.com T Becker, AM zu Vilsendorf, T Terbish, J Klempnauer, … - Transplantation, 2007 - journals.lww.com Transplantation. Wolters Kluwer Health | Lippincott Williams & Wilkins. All Issues. ... Cited by 4 - Related articles - BL Direct - All 4 versions
EK Kim, KB Kwon, MJ Han, MY Song, JH Lee, N … - International journal of …, 2007 - cat.inist.fr Cytokines produced by immune cells infiltrating pancreatic islets are important mediators of
ß-cell destruction in insulin-dependent diabetes mellitus. Cytokines stimulate an inducible form
of nitric oxide synthase(iNOS) expression and nitric oxide(NO) production, leading to ... Cited by 4 - Related articles - BL Direct - All 4 versions
