TP Di Lorenzo, M Peakman, BO Roep - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov T cell epitopes represent the molecular code words through which the adaptive
immune system communicates. In the context of a T cell-mediated autoimmune
disease such as type 1 diabetes, CD4 and CD8 T cell recognition of islet ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org T Takaki, MP Marron, CE Mathews, ST … - The Journal of Immunology, 2006 - Am Assoc Immnol In both humans and NOD mice, particular MHC genes are primary contributors to
development of the autoreactive CD4 + and CD8 + T cell responses against
pancreatic cells that cause type 1 diabetes (T1D). Association studies have ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by
T-cells, detection of these rare lymphocytes remains largely elusive. Suitable
T-cell assays are highly needed, since they could offer preclinical ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell
destruction in type 1 diabetes. However, few islet-associated peptides have been
demonstrated to activate autoreactive CTLs from type 1 diabetic subjects. ... Cited by 28 - Related articles - BL Direct - All 5 versions
JH Kessler, CJM Melief - Leukemia, 2007 - nature.com The effectiveness of T-cell-mediated immunotherapy of cancer depends on both an
optimal immunostimulatory context of the therapy and the proper selection with
respect to quality and quantity of the targeted tumor-associated antigens ... Cited by 23 - Related articles - BL Direct - All 3 versions
S Viatte, PM Alves, P Romero - Immunology and cell biology, 2006 - interscience.wiley.com Summary One of the challenges of tumour immunology remains the identification of
strongly immunogenic tumour antigens for vaccination. Reverse immunology, that
is, the procedure to predict and identify immunogenic peptides from the ... Cited by 14 - Related articles - BL Direct - All 5 versions
JH Kessler, SA Bres-Vloemans, PA van Veelen … - Leukemia, 2006 - nature.com For immunotherapy of residual disease in patients with Philadelphia-positive
leukemias, the BCR-ABL fusion regions are attractive disease-specific T-cell
targets. We analyzed these regions for the prevalence of cytotoxic T ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org E Martinuzzi, G Novelli, M Scotto, P Blancou, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—CD8 + T-cell reactivities were less frequent at follow-up, as 28.6% of
responses tested positive at type 1 diabetes diagnosis vs. 13.2% after a median
of 11 months (P = 0.003). While GAD and IA-2 autoantibody (aAb) titers were ... Cited by 12 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org P Blancou, R Mallone, E Martinuzzi, S Severe … - The Journal of Immunology, 2007 - Am Assoc Immnol Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic
cells. CD8 + T cells have recently been assigned a major role in cell injury.
Consequently, the identification of autoreactive CD8 + T cells in humans ... Cited by 10 - Related articles - All 6 versions
- ►diabetesjournals.org I Jarchum, JC Baker, T Yamada, T Takaki, MP … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—We found that HLA-A*0201-restricted T-cells isolated from the islets
of the transgenic mice were specific for Ins1 L3–11, Ins1 B5–14, and Ins1/2
A2–10. Insulin-reactive T-cells were present in the islets of mice as ... Cited by 10 - Related articles - BL Direct - All 4 versions
