- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized
proteins destined for the cell surface or released into the extracellular milieu. The study of protein
folding and trafficking within the ER is an extremely active area of research that has ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JA Emamaullee, AM Shapiro - Diabetes, 2006 - Am Diabetes Assoc A substantial proportion of the transplanted islet mass fails to engraft due to death by
apoptosis, and a number of strategies have been explored to inhibit β-cell loss. Inhibition of extrinsic
signals of apoptosis (ie, cFLIP or A20) have been explored in experimental islet ... Cited by 31 - Related articles - BL Direct - All 10 versions
HH Szeto - Antioxidants & Redox Signaling, 2008 - liebertonline.com It is now recognized that oxidative injury and mitochondrial dysfunction are responsible for many
clinical disorders with unmet needs, including ischemia–reperfusion injury,
neurodegeneration, and diabetes. Mito- chondrial dysfunction can lead to cell death by ... Cited by 23 - Related articles - BL Direct - All 4 versions
D vanderwindt, R Bottino, A Casu, N … - …, 2007 - interscience.wiley.com Abstract: Islets isolated from multiple pancreas donors are often necessary to achieve euglycemia
in type 1 diabetic patients treated by islet allotransplantation. This increases the burden on the
limited pool of donor organs. After infusion into the portal vein, a substantial percentage of ... Cited by 17 - Related articles - BL Direct - All 3 versions
B Armann, MS Hanson, E Hatch, A Steffen … - American journal of …, 2007 - pubmedcentral.nih.gov To validate this assay, lipid peroxidation and antioxidative defense capacity were evaluated
by detection of malondialdehyde (MDA) levels and glutathione peroxidase activity (GPx),
respectively. Also, flow cytometric analyses of ROS (dihydroethidine), apoptosis (Annexin ... Cited by 15 - Related articles - BL Direct - All 6 versions
S Marzorati, B Antonioli, R Nano, P Maffi, … - American Journal of …, 2006 - interscience.wiley.com A portion of transplanted islets is lost during engraftment as a result of stressful events, involving
hypoxia and production of proinflammatory molecules by islets. Two of these molecules (monocyte
chemoattractant protein-1, CCL2/MCP-1 and tissue factor, TF) are directly correlated with ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org H Mosen, A Salehi, R Henningsson, I … - Journal of …, 2006 - Soc Endocrinology We have studied the influence of nitric oxide (NO) and carbon monoxide (CO), putative messenger
molecules in the brain as well as in the islets of Langerhans, on glucose-stimulated insulin secretion
and on the activities of the acid -glucoside hydrolases, enzymes which we previously ... Cited by 10 - Related articles - BL Direct - All 3 versions
- ►asnjournals.org DA Thomas, C Stauffer, K Zhao, H Yang, VK … - Journal of the American …, 2007 - Am Soc Nephrol Apoptotic cell death is a defined pathway for islet cell demise, and mitochondrial dysfunction
contributes to islet cell apoptosis. The hypothesis that the novel peptide d-Arg-2',
6'-dimethyltyrosine-Lys-Phe-NH 2 (SS-31), previously shown to target inner mitochondrial ... Cited by 9 - Related articles - BL Direct - All 5 versions
C McCabe, A Samali, T O'Brien, HE … - Diabetes/Metabolism … - interscience.wiley.com Gene transfer to pancreatic islets may prove useful in preventing islet cell destruction and prolonging
islet graft survival after transplantation in patients with type 1 diabetes mellitus (T1DM).
Potentially, a host of therapeutically relevant transgenes may be incorporated into an ... Cited by 5 - Related articles - BL Direct - All 3 versions
CP Gheorghe, S Mohan, KC Oberg, LD … - Reproductive Sciences, 2007 - rsx.sagepub.com Hypoxia has been identified as a major stressor in placental and fetal development. To test the
hypoth- esis that hypoxic stress responses are associated with gene expression changes, the
authors measured gene expression in the mouse placenta in response to 48 hours of ... Cited by 5 - Related articles - BL Direct - All 3 versions
