- ►nih.gov A Hinek, AC Smith, EM Cutiongco, JW Callahan, … - The American Journal of …, 2000 - Elsevier Costello syndrome is characterized by mental retardation, loose skin, coarse face, skeletal
deformations, cardiomyopathy, and predisposition to numerous malignancies. The genetic origin
of Costello syndrome has not yet been defined. Using immunohistochemistry and ... Cited by 61 - Related articles - BL Direct - All 11 versions
- ►nih.gov TR Jahn, SE Radford - Archives of Biochemistry and Biophysics, 2008 - Elsevier Protein aggregation has now become recognised as an important and generic aspect of protein
energy landscapes. Since the discovery that numerous human diseases are caused by protein
aggregation, the biophysical characterisation of misfolded states and their aggregation ... Cited by 36 - Related articles - All 6 versions
- ►shouxi.net L Marzban, CJ Rhodes, DF Steiner, L Haataja, PA … - Diabetes, 2006 - Am Diabetes Assoc Islet amyloid, formed by aggregation of islet amyloid polypeptide (IAPP; amylin), is a pathological
characteristic of the pancreas in type 2 diabetes and may contribute to the progressive loss of
β-cells in this disease. We tested the hypothesis that impaired processing of the IAPP ... Cited by 18 - Related articles - BL Direct - All 5 versions
JF Paulsson, A Andersson, P Westermark, GT … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Islet amyloid is a frequent finding in the islets of Langerhans of individuals
with type 2 diabetes. The main amyloid constituent is the beta cell- derived polypeptide hormone
islet amyloid polypeptide (IAPP). In general, amyloid refers to an extracellular deposit of a ... Cited by 16 - Related articles - BL Direct - All 3 versions
- ►nih.gov IT Yonemoto, GJA Kroon, HJ Dyson, WE Balch, JW … - Biochemistry, 2008 - pubs.acs.org Human amylin, or islet amyloid polypeptide, is a peptide cosecreted with insulin by the beta cells
of the pancreatic islets of Langerhans. The 37-residue, C-terminally amidated human amylin
peptide derives from a proprotein that undergoes disulfide bond formation in the ... Cited by 11 - Related articles - All 5 versions
- ►nih.gov A Ostuni, B Bochicchio, MF Armentano, F Bisaccia, AM … - Biophysical Journal, 2007 - Elsevier One of the unusual properties of elastin is its ability to coacervate, which has been proposed
to play an important role in the alignment of monomeric elastin for cross-linking into the polymeric
elastin matrix. The temperature at which this transition takes place depends on several ... Cited by 7 - Related articles - BL Direct - All 8 versions
F Johan… - Experimental Diabetes Research, 2008 - hindawi.com Amyloid formation is cytotoxic and can activate the caspase cascade. Here, we monitor
caspase-3-like activity as reduction of fluorescence resonance energy transfer (FRET) using
the contstruct pFRET2-DEVD containing enhanced cyan fluorescent protin (EYFP) linked ... Cited by 6 - Related articles - Cached - All 8 versions
- ►diabetesjournals.org L Marzban, A Tomas, TC Becker, L Rosenberg, J … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Thioflavine S–positive amyloid deposits were clearly present after 10 days of
culture. Transduction with Ad-hProIAPP-siRNA reduced proIAPP expression by 75% compared
with nontransduced islets as assessed by Western blot analysis of islet lysates 4 days ... Cited by 5 - Related articles - All 3 versions
LK Phillips, M Horowitz - Current Opinion in Endocrinology, Diabetes …, 2006 - journals.lww.com Recent findings: Amylin plays a significant role in glucose homeostasis, particularly
postprandially, through slowing of gastric emptying and inhibition of glucagon release. Dysregulated
processing of the amylin precursor, pro islet amlyoid polypeptide, may result in amyloid ... Cited by 1 - Related articles - BL Direct - All 3 versions
AM Davalli, L Perego, F Bertuzzi, G Finzi, S La … - Cell …, 2008 - ingentaconnect.com To learn more about nonimmune-mediated islet graft failure, we transplanted different preparations
(preps) of isolated human islets under the kidney capsule of streptozotocin (STZ)-diabetic nude
mice. One month after the implantation of 1,000 or 2,000 islets, grafts were harvested for ... Cited by 1 - Related articles
