- ►nih.gov I Shafat, E Zcharia, B Nisman, Y Nadir, F … - Biochemical and biophysical research communications, 2006 - Elsevier Heparanase is a mammalian endo-β-d-glucuronidase that cleaves heparan sulfate
side chains at a limited number of sites. Heparanase enzymatic activity is
thought to participate in degradation and remodeling of the extracellular ... Cited by 37 - Related articles - All 6 versions
V Vreys, G David - Journal of Cellular and Molecular Medicine, 2007 - interscience.wiley.com Heparan sulphate proteoglycans are ubiquitous macromolecules of cell surfaces
and extracellular matrices. Numerous extracellular matrix proteins, growth
factors, morphogens, cytokines, chemokines and coagulation factors are ... Cited by 31 - Related articles - BL Direct - All 3 versions
L Baraz, Y Haupt, M Elkin, T Peretz, I … - Oncogene, 2006 - nature.com Mammalian heparanase degrades heparan sulfate, the most prominent polysaccharide
of the extracellular matrix. Causal involvement of heparanase in tumor
progression is well documented. Little is known, however, about mechanisms ... Cited by 24 - Related articles - BL Direct - All 5 versions
MJ Van Den Hoven, AL Rops, MA Bakker, J … - Kidney international, 2006 - nature.com In overt diabetic nephropathy (DNP), an increase in the permeability of the
glomerular basement membrane (GBM) has been associated with a loss of negatively
charged heparan sulfates (HS) in the GBM. Heparanase (HPSE), an endo- ... Cited by 24 - Related articles - BL Direct - All 7 versions
- ►asnjournals.org A Kramer, M van den Hoven, A Rops, T … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Heparan sulfate (HS) in the glomerular basement membrane (GBM) is important for
regulation of the charge-dependent permeability. Heparanase has been implicated
in HS degradation in several proteinuric diseases. This study analyzed the ... Cited by 21 - Related articles - BL Direct - All 8 versions
- ►asnjournals.org A Singh, SC Satchell, CR Neal, EA McKenzie … - Journal of the American Society of Nephrology, 2007 - Am Soc Nephrol Glycocalyx, composed of glycoproteins including proteoglycans, coats the luminal
surface of the glomerular capillaries. Human heparanase degrades heparan
sulphate glycosaminoglycans and is up-regulated in proteinuric states. In ... Cited by 17 - Related articles - All 4 versions
- ►adisonline.com [PDF] ME Williams - Drugs, 2006 - ingentaconnect.com Despite the worldwide epidemic of chronic kidney disease complicating Abstract
diabetes mellitus, current therapies directed against nephroprogression are
limited to angiotensin conversion or receptor blockade. Nonetheless, ... Cited by 16 - Related articles - BL Direct - All 8 versions
MJ Van Den Hoven, AL Rops, I Vlodavsky, V … - Kidney International, 2007 - medicine.uiowa.edu Heparanase is an endo-b(1–4)-D-glucuronidase that degrades heparan sulfate
(HS) polysaccharide side chains. The role of heparanase in metastasis,
angiogenesis, and inflammation has been established. Recent data suggest a ... Cited by 15 - Related articles - View as HTML - BL Direct - All 6 versions
JA Jefferson, SJ Shankland, RH Pichler - Kidney International, 2008 - nature.com Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an
independent risk factor for both renal disease progression, and cardiovascular
disease. Although the characteristic pathological changes in DKD include ... Cited by 13 - Related articles - All 3 versions
MJ Van Den Hoven, TJ Wijnhoven, JP Li, E … - Kidney International, 2007 - nature.com Heparan sulfate in the glomerular basement membrane has been considered crucial
for charge-selective filtration. In many proteinuric diseases, increased
glomerular expression of heparanase is associated with decreased heparan ... Cited by 12 - Related articles - BL Direct - All 5 versions
