J Beltowski - Atherosclerosis, 2006 - Elsevier Leptin, a 167-amino acid peptide hormone produced by white adipose tissue, is
primarily involved in the regulation of food intake and energy expenditure.
Leptin receptors are expressed in many tissues including the cardiovascular ... Cited by 92 - Related articles - All 18 versions
- ►nih.gov CA Papaharalambus, KK Griendling - Trends in cardiovascular medicine, 2007 - Elsevier The development of vascular disease has its origins in an initial insult to the
vessel wall by biological or mechanical factors. The disruption of homeostatic
mechanisms leads to alteration of the original architecture of the vessel ... Cited by 65 - Related articles - All 7 versions
- ►ahajournals.org R Yang, LA Barouch - Circulation Research, 2007 - Am Heart Assoc Leptin, among the best known hormone markers for obesity, exerts pleiotropic
actions on multiple organ systems. In this review, we summarize major leptin
signaling pathways, namely Janus-activated kinase/signal transducers and ... Cited by 28 - Related articles - All 4 versions
- ►physiology.org B Wagoner, DB Hausman, R Harris - … Journal of Physiology- Regulatory, Integrative and …, 2006 - Am Physiological Soc Leptin has been shown to reduce body fat in vivo. Adipocytes express the leptin
receptor; therefore, it is realistic to expect a direct effect of leptin on
adipocyte growth and metabolism. In vitro studies examining the effect of ... Cited by 18 - Related articles - BL Direct - All 3 versions
N Ouslimani, M Mahrouf, J Peynet, D … - Metabolism, 2007 - Elsevier Beyond its antihyperglycemic action, the antidiabetic oral drug metformin
possesses antioxidant properties that may contribute to improve the
cardiovascular deleterious effects of the diabetic disease. We explored ... Cited by 17 - Related articles - All 9 versions
HS Zhang, SQ Wang - Journal of molecular and cellular cardiology, 2006 - Elsevier Activated matrix metalloproteinases (MMPs) in patients with acute coronary
syndromes may contribute to plaque destabilization. Tumor necrosis factor-α
(TNF-α) enhances NAD (P) H oxidase-dependent reactive oxygen species (ROS) ... Cited by 17 - Related articles - All 9 versions
- ►biolreprod.org L Tosca, C Chabrolle, S Uzbekova, J Dupont - Biology of reproduction, 2007 - Soc Study Reprod In mammals, IGFs are important for the proliferation and steroidogenesis of
ovarian cells. Metformin is an insulin sensitizer molecule used for the
treatment of the infertility of women with polycystic ovary syndrome. It ... Cited by 16 - Related articles - BL Direct - All 4 versions
KI Paraskevas, CD Liapis, DP Mikhailidis - Current Drug Targets, 2006 - ingentaconnect.com Abstract: Leptin seems to regulate various physiological mechanisms besides body
weight. Leptin plays a role in vascu- lar biology and pathology as well as renal
function. In addition, leptin has been implicated in the regulation of ... Cited by 16 - Related articles - BL Direct - All 2 versions
- ►ahajournals.org KK Koh, SM Park, MJ Quon - Circulation, 2008 - Am Heart Assoc Insulin resistance, 8 systemic hypertension, and hypercholesterolemia 9 all
contribute independently to vascular endothelial dysfunction that promotes
atherosclerosis and coronary heart disease. Reciprocal relationships ... Cited by 13 - Related articles - All 8 versions
