- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
- ►endojournals.org CY Lin, T Gurlo, L Haataja, WA Hsueh, PC … - Journal of Clinical …, 2005 - Endocrine Soc Methods and Results: Vehicle or h-IAPP was applied to human islets with or without RSG (10
and 50 µM) for 48 h. A 2-fold increase in the number of terminal deoxynucleotidyl
transferase-mediated deoxy-UTP nick end labeling-positive nuclei was detected in ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin secretion, loss
of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet amyloid is derived
from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted with ... Cited by 28 - Related articles - BL Direct - All 4 versions
JF Paulsson, A Andersson, P Westermark, GT … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Islet amyloid is a frequent finding in the islets of Langerhans of individuals
with type 2 diabetes. The main amyloid constituent is the beta cell- derived polypeptide hormone
islet amyloid polypeptide (IAPP). In general, amyloid refers to an extracellular deposit of a ... Cited by 16 - Related articles - BL Direct - All 3 versions
- ►geyseco.info [PDF] JJ Meier - Diabetologia, 2008 - Springer Abstract Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement
of beta cell function is therefore the logical long-term solution to therapy. This review sets out
to describe the defects in beta cell mass and function in both forms of diabetes, summa- ... Cited by 16 - Related articles - BL Direct - All 6 versions
IW Campbell, S Mariz - Diabetes research and clinical practice, 2007 - Elsevier Progressive β-cell dysfunction and β-cell failure are fundamental pathogenic features of type
2 diabetes. Ultimately, the development and continued progression of diabetes is a consequence
of the failure of the β-cell to overcome insulin resistance. Strategies that aim to prevent ... Cited by 13 - Related articles - All 11 versions
- ►nih.gov S Zraika, RL Hull, J Udayasankar, KM Utzschneider … - … and biophysical research …, 2007 - Elsevier Islet amyloid contributes to the loss of β-cell mass in type 2 diabetes. To examine the roles of
glucose and time on amyloid formation, we developed a rapid in vitro model using isolated islets
from human islet amyloid polypeptide (hIAPP) transgenic mice. Islets from hIAPP ... Cited by 12 - Related articles - All 6 versions
C Ersoy, S Kiyici, F Budak, B Oral, M Guclu, C … - Diabetes Research and …, 2008 - Elsevier The aim of the study was to evaluate the effect of metformin on markers of endothelial
function, vascular inflammation and factors of thrombosis in obese type 2 diabetic patients.
Twenty-four type 2 diabetic patients (15 female, 9 male) previously under medical ... Cited by 9 - Related articles - All 12 versions
- ►diabetesjournals.org S Zraika, RL Hull, J Udayasankar, A Clark, KM … - Diabetes, 2007 - Am Diabetes Assoc Islet amyloid contributes to loss of β-cell mass and function in type 2 diabetes. It is poorly understood
how the building block of amyloid, islet amyloid polypeptide (IAPP), misfolds and accumulates
within the islet to contribute to cellular dysfunction. We sought to determine whether ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►physiology.org N Rasouli, PA Kern, EA Reece, SC … - American Journal of …, 2007 - Am Physiological Soc Thiazolidinediones (TZDs) and metformin decreased the incidence of diabetes in subjects at
risk for developing diabetes and improved peripheral or hepatic insulin sensitivity,
respectively. Whether they also directly improved -cell function is not clear. In vitro studies ... Cited by 8 - Related articles - BL Direct - All 7 versions
