- ►endojournals.org IS Farooqi, S O'Rahilly - Endocrine Reviews, 2006 - Endocrine Soc CHANGES IN DIET and physical activity have driven the rise in the prevalence of
adult and childhood obesity over a relatively short time interval (1, 2).
However, it is important to recognize the significant contribution of ... Cited by 88 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M López, CJ Lelliott, S Tovar, W Kimber, R … - Diabetes, 2006 - Am Diabetes Assoc Fatty acid metabolism in the hypothalamus has recently been shown to regulate
feeding. The selective estrogen receptor modulator tamoxifen (TMX) exerts a
potent anorectic effect. Here, we show that the anorectic effect of TMX is ... Cited by 38 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org IS Farooqi, S Drop, A Clements, JM Keogh, J … - Diabetes, 2006 - Am Diabetes Assoc Congenital deficiency of proopiomelanocortin (POMC) results in a syndrome of
hypoadrenalism, severe obesity, and altered skin and hair pigmentation. The
concept that subtle variation in POMC expression and/or function might ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►simplifica.net [PDF] M López, S Tovar, MJ Vázquez, LM Williams, … - Proceedings of the Nutrition Society, 2007 - Cambridge Univ Press More than 70 years ago the glucostatic, lipostatic and aminostatic hypotheses
proposed that the central nervous system sensed circulating levels of different
metabolites, changing feeding behaviour in response to the levels of those ... Cited by 19 - Related articles - BL Direct - All 10 versions
- ►endojournals.org AW Xu, L Ste-Marie, CB Kaelin, GS Barsh - Endocrinology, 2007 - Endocrine Soc Leptin is an adipocyte-derived hormone that signals body energy status to the
brain by acting on multiple neuronal subgroups in the hypothalamus, including
those that express proopiomelanocortin (Pomc) and agouti-related protein ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►jbc.org GG Lavery, EA Walker, N Turan, D Rogoff, JW … - Journal of Biological Chemistry, 2008 - ASBMB Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose
phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for
ER enzymes. In liver H6PD is required for the 11-oxoreductase activity of ... Cited by 14 - Related articles - All 6 versions
- ►nih.gov D Chida, S Nakagawa, S Nagai, H Sagara, H … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences ACTH (ie, corticotropin) is the principal regulator of the
hypothalamus–pituitary–adrenal axis and stimulates steroidogenesis in the
adrenal gland via the specific cell-surface melanocortin 2 receptor (MC2R). ... Cited by 13 - Related articles - BL Direct - All 8 versions
A Oswal, GS Yeo - Obesity Reviews, 2007 - interscience.wiley.com The recent rapid increase in the prevalence of obesity across the world is
undoubtedly due to changes in diet and lifestyle. However, it is also
indisputable that different people react differently to this change in ... Cited by 10 - Related articles - BL Direct - All 3 versions
V Tolle, MJ Low - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Hyperphagic POMC-deficient mice were more sensitive than wild-type
mice to the anorectic effects of MTII. Hypothalamic melanocortin-3 (MC3)/4-R
mRNAs in POMC-deficient mice were unchanged, suggesting increased receptor ... Cited by 9 - Related articles - BL Direct - All 4 versions
- ►endojournals.org YC Tung, SJ Piper, D Yeung, S O'Rahilly, AP … - Endocrinology, 2006 - Endocrine Soc Functional disruption of either MC3R or MC4R results in obesity, implicating
both in the control of energy homeostasis. The ligands for these receptors are
derived from the prohormone proopiomelancortin (POMC), which is ... Cited by 10 - Related articles - BL Direct - All 3 versions
