N Pub - Nature medicine, 2006 - med.nagoya-u.ac.jp Understanding the pathways involved in xenograft rejection will aid the rational design of interventional
protocols. Elimination of the galactose a-1,3-galactose (Gal) epitope prevented hyperacute rejection
of pig-to-nonhuman primate (NHP) solid-organ xenografts1. In contrast, the Gal epitope ... Cited by 140 - Related articles - BL Direct - All 9 versions
M Brissova, A Shostak, M Shiota, PO Wiebe, G … - Diabetes, 2006 - Am Diabetes Assoc To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic factors
and their receptors in differentiating endocrine cells and adult islets. Using intravital lectin ... Cited by 40 - Related articles - BL Direct - All 6 versions
V Cantaluppi, L Biancone, GM Romanazzi … - American Journal of …, 2006 - interscience.wiley.com Donor intra-islet endothelial cells contribute to neovascularization after transplantation. Several
factors may interfere with this process and ultimately influence islet engraftment. Rapamycin,
a central immunosuppressant in islet transplantation, is an mTOR inhibitor that has been ... Cited by 27 - Related articles - BL Direct - All 5 versions
R Olsson, A Maxhuni, PO Carlsson - Transplantation, 2006 - journals.lww.com Despite improved immunosuppressive treatments in re- cent years, long-term insulin independence
is still very poor following clinical islet transplantation (1). Continued focus on advancing immunological
therapies is essential. However, experimental data indicate that even in the synge- neic ... Cited by 13 - Related articles - BL Direct - All 5 versions
T Linn, J Schmitz, I Hauck- … - Clinical and …, 2006 - pubmedcentral.nih.gov Clinical diabetes is associated with progressive loss of the insulin producing β-cells of the endocrine
pancreas. Type-1 diabetes is an autoimmune disease characterized by activation of the
Th1-phenotype, lymphocytic infiltration of pancreatic islets, and programmed cell death of ... Cited by 12 - Related articles - BL Direct - All 6 versions
- ►duke.edu [PDF] N Iwashita, T Uchida, JB Choi, K Azuma, T Ogihara, N … - Diabetologia, 2007 - Springer Page 1. ARTICLE Impaired insulin secretion in vivo but enhanced insulin secretion from
isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A
knock-out mice N. Iwashita & T. Uchida & JB Choi & K. Azuma & ... Cited by 11 - Related articles - BL Direct - All 5 versions
S Speier, D Nyqvist, O Cabrera, J Yu, RD Molano, A … - Nature Medicine, 2008 - nature.com Advanced imaging techniques have become a valuable tool in the study of complex biological
processes at the cellular level in biomedical research. Here, we introduce a new technical platform
for noninvasive in vivo fluorescence imaging of pancreatic islets using the anterior ... Cited by 9 - Related articles - BL Direct - All 3 versions
AJF King, JR Fernandes, J Hollister-Lock, CE Nienaber … - Diabetes, 2007 - Am Diabetes Assoc Islets are composed mostly of β-cells, and therefore stem cell research has concentrated on generating
purified β-cells, neglecting the other endocrine cell types in the islet. We investigated the presence
of endocrine non–β-cells after islet transplantation. In addition, we studied whether the ... Cited by 8 - Related articles - BL Direct - All 4 versions
A Bharat, D Saini, N Benshoff, J Goodman, NM Desai … - Transplantation, 2007 - journals.lww.com Background. Intra-islet endothelial cells (IECs) express high levels of major histocompatibility
complex (MHC) and are pivotal for posttransplant islet revascularization. We postulated that
donor-specific sensitization would result in hyperacute rejection of IECs and prevent islet ... Cited by 8 - Related articles - BL Direct - All 4 versions
