- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 196 - Related articles - BL Direct - All 7 versions
W Wente, AM Efanov, M Brenner, A … - Diabetes, 2006 - Am Diabetes Assoc Fibroblast growth factor-21 (FGF-21) is a recently discovered metabolic
regulator. Here, we investigated the effects of FGF-21 in the pancreatic
β-cell. In rat islets and INS-1E cells, FGF-21 activated extracellular ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►nih.gov MG Latour, T Alquier, E Oseid, C Tremblay, TL … - Diabetes, 2007 - Am Diabetes Assoc Long-chain fatty acids amplify insulin secretion from the pancreatic β-cell.
The G-protein–coupled receptor GPR40 is specifically expressed in β-cells and
is activated by fatty acids; however, its role in acute regulation of ... Cited by 47 - Related articles - BL Direct - All 6 versions
- ►nih.gov T Morioka, E Asilmaz, J Hu, JF Dishinger, AJ … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig 1 Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA. 2
Laboratory of Molecular Genetics, The Rockefeller University, New York, New
York, USA. 3 Departments of Chemistry and Pharmacology, University of ... Cited by 36 - Related articles - BL Direct - All 10 versions
- ►shouxi.net R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological Chemistry, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and
mass in patients with diabetes is possible. A regenerative approach may
represent an alternative treatment option relative to current diabetes ... Cited by 29 - Related articles - All 7 versions
M Prentki, CJ Nolan - 临床研究杂志, 2006 - journal.shouxi.net The major focus of this Review is on the mechanisms of islet ? cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of ? cell compensation for insulin resistance, ... Cited by 30 - Related articles - Cached - All 2 versions
NN Danial, LD Walensky, CY Zhang, CS Choi, … - Nature - unthsc.edu The proapoptotic BCL-2 family member BAD resides in a glucokinase-containing
complex that regulates glucose-driven mitochondrial respiration. Here, we
present genetic evidence of a physiologic role for BAD in ... Cited by 27 - Related articles - View as HTML - BL Direct - All 7 versions
- ►shouxi.net M Peshavaria, BL Larmie, J Lausier, B Satish, … - Diabetes, 2006 - Am Diabetes Assoc The pancreatic β-cell has a substantial capacity to functionally compensate in
response to physiological and pathophysiological changes in tissue insulin
requirements. A fundamental aspect of this response is the dynamic ... Cited by 23 - Related articles - BL Direct - All 5 versions
BA Menge, A Tannapfel, O Belyaev, R Drescher … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Protocol 1: fasting glucose concentrations increased significantly
after the 50% pancreatectomy (P = 0.01), but the fractional β-cell area of the
pancreas remained unchanged (P = 0.11). β-Cell proliferation, the overall ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►nih.gov DA Babu, TG Deering, RG Mirmira - Molecular genetics and metabolism, 2007 - Elsevier Emerging evidence over the past decade indicates a central role for
transcription factors in the embryonic development of pancreatic islets and the
consequent maintenance of normal glucose homeostasis. Pancreatic and ... Cited by 17 - Related articles - All 3 versions
