- ►nih.gov SP Weisberg, D Hunter, R Huber, J … - Journal of Clinical …, 2005 - Am Soc Clin Investig The CC motif chemokine receptor–2 (CCR2) regulates monocyte and macrophage recruitment
and is necessary for macrophage-dependent inflammatory responses and the development
of atherosclerosis. Although adipose tissue expression and circulating concentrations of ... Cited by 318 - Related articles - BL Direct - All 14 versions
ED Rosen, BM Spiegelman - Nature, 2006 - nature.com Adipocytes have been studied with increasing intensity as a result of the emergence of obesity
as a serious public health problem and the realization that adipose tissue serves as an integrator
of various physiological pathways. In particular, their role in calorie storage makes ... Cited by 227 - Related articles - BL Direct - All 6 versions
SE Shoelson, L Herrero, A Naaz - Gastroenterology, 2007 - Elsevier Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin
resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty
liver disease. A chronic, subacute state of inflammation often accompanies the ... Cited by 149 - Related articles - All 23 versions
V Emilsson, G Thorleifsson, B Zhang, AS Leonardson, … - Nature, 2008 - nature.com Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity and
causes of such diseases. To elucidate the complexity of common human diseases such ... Cited by 137 - Related articles - BL Direct - All 11 versions
TJ Guzik, D Mangalat, R Korbut - Journal Of Physiology and Pharmacology, 2006 - jpp.krakow.pl Obesity and obesity related diseases are a major public health problem. Recent studies have
shown that fat tissue is not a simple energy storage organ, but exerts important endocrine and
immune functions. These are achieved predominantly through release of adipocytokines, ... Cited by 130 - Related articles - Cached - BL Direct - All 6 versions
- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts
for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM
are increasingly focused on disordered lipid metabolism. Here we review recent human ... Cited by 113 - Related articles - BL Direct - All 5 versions
PA Permana, C Menge, PD Reaven - Biochemical and biophysical research …, 2006 - Elsevier Macrophage infiltration into adipose tissue increases with obesity, a condition associated with
low-grade inflammation and insulin resistance. We investigated the direct effects of
macrophage-secreted factors on adipocyte inflammation and insulin resistance. 3T3-L1 ... Cited by 106 - Related articles - All 5 versions
- ►endojournals.org AM Sharma, B Staels - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Conclusions: PPAR is highly expressed in adipose tissue, where its activation with thiazolidinediones
alters fat topography and adipocyte phenotype and up-regulates genes involved in fatty acid
metabolism and triglyceride storage. Furthermore, PPAR activation is associated with ... Cited by 99 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org CN Lumeng, SM DeYoung, JL Bodzin, AR Saltiel - Diabetes, 2007 - Am Diabetes Assoc Although recent studies show that adipose tissue macrophages (ATMs) participate in the inflammatory
changes in obesity and contribute to insulin resistance, the properties of these cells are not well
understood. We hypothesized that ATMs recruited to adipose tissue during a high-fat diet ... Cited by 88 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org A Kotronen, H Yki-Jarvinen - Arteriosclerosis, Thrombosis, and …, 2008 - Am Heart Assoc Although the epidemic of obesity has been accompanied by an increase in the prevalence of
the metabolic syndrome, not all obese develop the syndrome and even lean individuals can
be insulin resistant. Both lean and obese insulin resistant individuals have an excess of ... Cited by 82 - Related articles - All 6 versions
