SK Iyengar, HE Abboud, KAB Goddard, MF Saad, SG … - Diabetes, 2007 - Am Diabetes Assoc The Family Investigation of Nephropathy and Diabetes (FIND) was initiated to map genes underlying
susceptibility to diabetic nephropathy. A total of 11 centers participated under a single collection
protocol to recruit large numbers of diabetic sibling pairs concordant and discordant for ... Cited by 37 - Related articles - BL Direct - All 8 versions
AM Osterholm, B He, J Pitkaniemi, L Albinsson, T Berg … - Kidney International, 2006 - nature.com Diabetic nephropathy (DN) is the primary cause of morbidity and mortality in patients with type
1 as well as type 2 diabetes, and accounts for 40% of end-stage renal disease in the Western
world. Familial clustering of DN suggests importance of genetic factors in the ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org BI Freedman, PJ Hicks, MM Sale, ED Pierson, CD … - Nephrology Dialysis …, 2007 - ERA-EDTA Background. Four linkage analyses have identified a region on chromosome 18q22-23 that appears
to harbour a diabetic nephropathy (DN) susceptibility locus. A trinucleotide repeat sequence
in exon 2 of the carnosinase gene (CNDP1) residing on 18q22.3 was subsequently ... Cited by 32 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org BI Freedman, M Bostrom, P Daeihagh, DW … - Clinical Journal of the …, 2007 - Am Soc Nephrol Several genes that predispose to type 2 diabetes have recently been identified. In addition to
the recognized and powerful effects of environmental factors, there is abundant evidence in support
of genetic susceptibility to the microvascular complication of nephropathy in individuals ... Cited by 25 - Related articles - All 3 versions
SG Satko, JR Sedor, SK Iyengar, BI … - Seminars in …, 2007 - interscience.wiley.com The incidence and prevalence rates of most forms of chronic kidney disease (CKD) had steadily
been increasing for the past 30 years, although these rates now appear to have reached a
plateau. It is clear that an individual's likelihood of developing progressive CKD results ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org JM Leon, BI Freedman, MB Miller, KE North, SC … - Nephrology Dialysis …, 2007 - ERA-EDTA Results. The phenotypic correlation between ACR and GFR was not significant in EAs (r =
0.04) and significantly negative in AAs (r = –0.17). Univariate analyses of ACR showed suggestive
evidence of linkage on chromosomes 8, 16 and 17 (LOD: 2–2.8) in AAs, on chromosomes ... Cited by 18 - Related articles - BL Direct - All 4 versions
S Dronavalli, I Duka, GL Bakris… - Nat Clin Pract Endocrinol Metab, 2008 - mp.medscape.com Between 20% and 40% of patients with diabetes ultimately develop diabetic nephropathy, which
in the US is the most common cause of endstage renal disease requiring dialysis. Diabetic nephropathy
has several distinct phases of development and multiple mechanisms contribute to the ... Cited by 17 - Related articles - Cached - All 6 versions
KJ Jager, VS Stel, C Wanner, C Zoccali, FW Dekker - Kidney International, 2007 - nature.com In studies on the effects of therapy (or other interventions), the randomized controlled trial
(RCT) is an almost unbeatable standard in clinical research. The value of RCTs leaves unabated
the valuable contributions of observational studies to medicine. This paper discusses ... Cited by 15 - Related articles - BL Direct - All 3 versions
AR HIPKISS - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2006 - biovita.fi ABSTRACT: Carnosine (ß-alanyl-L-histidine) is found exclusively in an- imal tissues. Carnosine
has the potential to suppress many of the bio- chemical changes (eg, protein oxidation,
glycation, AGE formation, and cross-linking) that accompany aging and associated ... Cited by 15 - Related articles - View as HTML - BL Direct - All 8 versions
BI Freedman, DW Bowden, MM Sale, CD Langefeld, … - Hypertension, 2006 - Am Heart Assoc Familial aggregation of albuminuria, DN, and ESRD have long been observed. 3,4 The magnitude
of familial aggregation of ESRD was demonstrated in a study of 25 883 incident dialysis
patients. 5 After exclusion of cases with monogenic genetic kidney diseases (ie, ... Cited by 13 - Related articles - All 6 versions
