R Saxena, L Gianniny, NP Burtt, V Lyssenko, C … - Diabetes, 2006 - Am Diabetes Assoc Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased
risk of type 2 diabetes in samples from Iceland, Denmark, and the US We genotyped 13 single
nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based ... Cited by 160 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org W Winckler, MN Weedon, RR Graham, SA McCarroll, S … - Diabetes, 2007 - Am Diabetes Assoc An important question in human genetics is the extent to which genes causing monogenic forms
of disease harbor common variants that may contribute to the more typical form of that
disease. We aimed to comprehensively evaluate the extent to which common variation in ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org HN Lyon, JC Florez, T Bersaglieri, R Saxena, W … - Diabetes, 2006 - Am Diabetes Assoc The common missense single nucleotide polymorphism (SNP) K121Q in the ectoenzyme nucleotide
pyrophosphate phosphodiesterase (ENPP1) gene has recently been associated with type 2
diabetes in Italian, US, and South-Asian populations. A three-SNP haplotype, including ... Cited by 48 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org CJ Willer, LL Bonnycastle, KN Conneely, WL Duren, … - Diabetes, 2007 - Am Diabetes Assoc More than 120 published reports have described associations between single nucleotide polymorphisms
(SNPs) and type 2 diabetes. However, multiple studies of the same variant have often been
discordant. From a literature search, we identified previously reported type 2 diabetes– ... Cited by 43 - Related articles - BL Direct - All 6 versions
MN Weedon, KR Owen, B Shields, G Hitman, M Walker … - Diabetes, 2005 - Am Diabetes Assoc HNF1α (TCF1) is a key transcription factor that is essential for pancreatic β-cell development
and function. Rare mutations of HNF1α cause maturity-onset diabetes of the young. A common
variant, G319S, private to the Oji-Cree population, predisposes to type 2 diabetes, but the ... Cited by 38 - Related articles - BL Direct - All 7 versions
LL Bonnycastle, CJ Willer, KN Conneely, AU Jackson, … - Diabetes, 2006 - Am Diabetes Assoc Prior reports have suggested that variants in the genes for maturity-onset diabetes of the young
(MODY) may confer susceptibility to type 2 diabetes, but results have been conflicting and coverage
of the MODY genes has been incomplete. To complement our previous studies of HNF4A, ... Cited by 40 - Related articles - BL Direct - All 10 versions
S Ellard, K Colclough - Human mutation, 2006 - interscience.wiley.com Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes mellitus characterized
by autosomal dominant inheritance, early age of onset (often <25 years of age), and pancreatic
-cell dysfunction. MODY is both clinically and genetically heterogeneous, with six different ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►nih.gov MI McCarthy, E Zeggini - Current Diabetes Reports, 2006 - Springer Introduction The growing prevalence of type 2 diabetes and obesity in societies worldwide is
widely recognized as among the greatest threats to global health in the coming century [1].
Nevertheless, we remain far from a comprehensive understanding of the molecular ... Cited by 31 - Related articles - BL Direct - All 8 versions
JC Florez - Diabetologia, 2008 - Springer Abstract Although type 2 diabetes has been traditionally understood as a metabolic disorder
initiated by insulin resistance, it has recently become apparent that an impairment in insulin secretion
contributes to its mani- festation and may play a prominent role in its early ... Cited by 31 - Related articles - BL Direct - All 3 versions
M Vaxillaire, P Froguel - Endocrinology and metabolism clinics of North America, 2006 - Elsevier Type 2 diabetes mellitus (T2D) is a heterogeneous metabolic disease occurring with concomitant
or interdependent defects of insulin secretion and action [1] and [2]. It generally is accepted that
T2D results from a complex interplay of genetic and environmental factors influencing ... Cited by 30 - Related articles - All 4 versions
