- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal
link between diabetes and diabetic complications. Four major molecular mechanisms have been
implicated in hyperglycemia-induced tissue damage: activation of protein kinase C (PKC) ... Cited by 120 - Related articles - All 7 versions
B Cannon, IG Shabalina, TV Kramarova, N Petrovic, J … - BBA-Bioenergetics, 2006 - Elsevier A physiological function of the original uncoupling protein, UCP1, is well established: UCP1
is the molecular background for nonshivering thermogenesis. The functions of the “novel”
UCPs, UCP2 and UCP3, are still not established. Recent discussions imply that all UCPs ... Cited by 55 - Related articles - All 4 versions
- ►nih.gov AE Civitarese, B Ukropcova, S Carling, M Hulver, RA … - Cell metabolism, 2006 - Elsevier Insulin resistance is associated with impaired skeletal muscle oxidation capacity and reduced
mitochondrial number and function. Here, we report that adiponectin signaling regulates mitochondrial
bioenergetics in skeletal muscle. Individuals with a family history of type 2 diabetes ... Cited by 56 - Related articles - All 15 versions
- ►fasebj.org V Bezaire, EL Seifert, ME Harper - The FASEB Journal, 2007 - FASEB Uncoupling protein (UCP) 3 (UCP3) is a mitochondrial anion carrier protein with highly selective
expression in skeletal muscle. Despite a great deal of interest, to date neither its molecular mechanism
nor its biochemical and physiological functions are well understood. Based on its high ... Cited by 49 - Related articles - BL Direct - All 4 versions
K Maiese, SD Morhan, ZZ Chong - Current neurovascular …, 2007 - pubmedcentral.nih.gov Diabetes mellitus (DM) affects approximately 170 million individuals worldwide and is expected
to alter the lives of at least 366 million individuals within a future span of 25 years. Of even greater
concern is the premise that these projections are underestimated since they assume ... Cited by 46 - Related articles - BL Direct - All 6 versions
KS Echtay - Free Radical Biology and Medicine, 2007 - Elsevier The physiological functions of the mitochondrial uncoupling proteins (UCP2 and UCP3) are still
under debate. There is, however, ample evidence to indicate that, in contrast to UCP1, they are
not crucial for nonshivering thermogenesis and do not catalyze the basal proton ... Cited by 47 - Related articles - All 3 versions
DR Gable, JW Stephens, JA Cooper, GJ Miller, SE … - Diabetes, 2006 - Am Diabetes Assoc The impact of the UCP2 −866G>A and UCP3 −55C>T variants on prospective risk of type 2 diabetes
was examined over 15 years in 2,936 healthy middle-aged men (mean age 56 years). Conversion
to diabetes (n = 169) was associated with higher BMI, blood pressure, cholesterol, ... Cited by 39 - Related articles - BL Direct - All 6 versions
P Schrauwen, J Hoeks, MKC Hesselink - Progress in Lipid Research, 2006 - Elsevier The discovery of the human homologue of the thermogenic protein UCP1, named uncoupling
protein 3 (UCP3), boosted research on the role of this skeletal muscle protein in energy metabolism
and body weight regulation. Nowadays, 9 years after its discovery emerging data indicate ... Cited by 31 - Related articles - All 2 versions
CS Stump, EJ Henriksen, Y Wei, JR Sowers - Annals of Medicine, 2006 - informahealthcare.com Skeletal muscle constitutes the largest insulin‐sensitive tissue in the body and is the primary
site for insulin‐stimulated glucose utilization. Skeletal muscle resistance to insulin is fundamental
to the metabolic dysregulation associated with obesity and physical inactivity, and ... Cited by 31 - Related articles - BL Direct - All 8 versions
- ►physoc.org M Mogensen, M Bagger, PK Pedersen, M … - The Journal of …, 2006 - Physiological Soc The purpose of this study was to investigate the hypothesis that cycling efficiency in vivo is related
to mitochondrial efficiency measured in vitro and to investigate the effect of training status on
these parameters. Nine endurance trained and nine untrained male subjects ( , ... Cited by 28 - Related articles - BL Direct - All 12 versions
