R Marone, V Cmiljanovic, B Giese, MP … - BBA-Proteins and Proteomics, 2008 - Elsevier Phosphoinositide 3-kinases (PI3K) orchestrate cell responses including mitogenic
signaling, cell survival and growth, metabolic control, vesicular trafficking,
degranulation, cytoskeletal rearrangement and migration. Deregulation of ... Cited by 82 - Related articles - All 2 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM … - Diabetes, 2006 - Am Diabetes Assoc Increased accumulation of fatty acids and their derivatives can impair
insulin-stimulated glucose disposal by skeletal muscle. To characterize the
nature of the defects in lipid metabolism and to evaluate the effects of ... Cited by 78 - Related articles - BL Direct - All 5 versions
B Draznin - Diabetes, 2006 - Am Diabetes Assoc Initial attempts to unravel the molecular mechanism of insulin resistance have
strongly suggested that a defect responsible for insulin resistance in the
majority of patients lies at the postreceptor level of insulin signaling. ... Cited by 51 - Related articles - BL Direct - All 5 versions
H Sell, D Dietze-Schroeder, J Eckel - Trends in Endocrinology & Metabolism, 2006 - Elsevier Insulin resistance in skeletal muscle is linked to an elevated adipose tissue
mass, as is found in obesity, but can also be observed in lipodystrophy, in
which adipose tissue is greatly reduced. Adipose tissue releases endocrine ... Cited by 47 - Related articles - All 3 versions
- ►nih.gov S Schenk, JF Horowitz - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Fatty acid oversupply is a key mediator of skeletal muscle insulin resistance in
obesity, primarily via accumulation of fatty acid metabolites and activation of
proinflammatory pathways. Herein, we demonstrate that fatty acid–induced ... Cited by 47 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org A Sriwijitkamol, C Christ-Roberts, R Berria, … - Diabetes, 2006 - Am Diabetes Assoc Skeletal muscle insulin resistance plays a key role in the pathogenesis of type
2 diabetes. It recently has been hypothesized that excessive activity of the
inhibitor of B (I B)/nuclear factor B (NF B) inflammatory pathway is a ... Cited by 45 - Related articles - BL Direct - All 4 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor
in the etiology of a number of diseases, including type 2 diabetes. In this
review, we discuss potential mechanisms by which brief nutrient excess and ... Cited by 46 - Related articles - All 12 versions
- ►endocrinology-journals.org E Hirsch, C Costa, E Ciraolo - Journal of Endocrinology, 2007 - Soc Endocrinology In multicellular organisms, concerted actions of different tissues are regulated
inside single cells by signal transduction mechanisms that, subsequently to
hormones sensing, trigger intracellular responses. In recent years, ... Cited by 37 - Related articles - BL Direct - All 3 versions
A Carracedo, PP Pandolfi - Oncogene, 2008 - nature.com The tumor suppressor PTEN was originally identified as a negative regulator of
the phosphoinositide 3-kinase (PI3K) signaling, a main regulator of cell growth,
metabolism and survival. Yet this function of PTEN is extremely relevant ... Cited by 37 - Related articles - All 2 versions
- ►nih.gov RV Farese, MP Sajan, H Yang, P Li, S … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig 1 James A. Haley Veterans Medical Center, Tampa, Florida, USA. 2 Roskamp
Institute, Sarasota, Florida, USA. 3 Department of Internal Medicine and
Department of Molecular Medicine, University of South Florida College of ... Cited by 34 - Related articles - BL Direct - All 8 versions
