- ►nih.gov DE Cummings, J Overduin - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable body
weight, because overall caloric ingestion and expenditure are exquisitely matched over long
periods of time, through the process of energy homeostasis. The brain receives hormonal, ... Cited by 152 - Related articles - BL Direct - All 10 versions
KG Murphy, SR Bloom - NATURE-LONDON-, 2006 - cms1.daegu.ac.kr Energy balance is a homeostatic system. Although malfunctions of this system can cause
obesity1, the relatively recent increase in the incidence of obesity is not thought to be the result
of specific defects, but of a regulatory system unable to cope with the current context of ... Cited by 94 - Related articles - View as HTML - BL Direct - All 8 versions
- ►nih.gov DJ Drucker - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The gastrointestinal tract has a crucial role in the control of energy homeostasis through its role
in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals from
the gastrointestinal tract are important regulators of gut motility and satiety, both of which ... Cited by 87 - Related articles - BL Direct - All 11 versions
DJ Drucker - Nature Clinical Practice Endocrinology and Metabolism, 2005 - glucagon.com INTRODUCTION Before the cDNAs and genes encoding pro glucagon were cloned, pancreatic
glucagon was the prin- cipal proglucagon-derived peptide (PGDP) with well-characterized biologic
actions. However, antisera directed against glucagon detected not only circulating ... Cited by 60 - Related articles - View as HTML - BL Direct - All 6 versions
AM Wren, SR Bloom - Gastroenterology, 2007 - Elsevier Many peptides are synthesized and released from the gastrointestinal tract. Although their roles
in the regulation of gastrointestinal function have been known for some time, it is now evident
that they also physiologically influence eating behavior. Our understanding of how ... Cited by 59 - Related articles - All 22 versions
GA Bray, DH Ryan - Gastroenterology, 2007 - Elsevier Three medications with approval for long-term use in the treatment of obesity are currently available
in the United States. Sibutramine (US Food and Drug Administration [FDA] approved in
1997), orlistat (FDA approved in 1999), and rimonabant (available in Europe and given ... Cited by 48 - Related articles - All 20 versions
K Wynne, AJ Park, CJ Small, K Meeran, MA … - International Journal of …, 2006 - nature.com International Journal of Obesity is a monthly, multi-disciplinary forum for papers describing basic,
clinical and applied studies in biochemistry, genetics and nutrition, together with molecular,
metabolic, psychological and epidemiological aspects of obesity and related disorders.
Cited by 45 - Related articles - BL Direct - All 4 versions
- ►endojournals.org KG Murphy, WS Dhillo, SR Bloom - Endocrine reviews, 2006 - Endocrine Soc Gut hormones signal to the central nervous system to influence energy homeostasis. Evidence
supports the existence of a system in the gut that senses the presence of food in the gastrointestinal
tract and signals to the brain via neural and endocrine mechanisms to regulate short-term ... Cited by 42 - Related articles - BL Direct - All 6 versions
JCG Halford - Current Opinion in Investigational Drugs, 2006 - biomedcentral.com A number of anti-obesity drugs are currently undergoing clinical development. These
include: (i) centrally-acting drugs, such as the noradrenergic and dopaminergic reuptake inhibitor
radafaxine, the endocannabinoid antagonist rimonabant, the selective serotonin 5-HT 2C ... Cited by 40 - Related articles - View as HTML - BL Direct - All 7 versions
O Chaudhri, C Small, S Bloom - … Transactions of the …, 2006 - rstb.royalsocietypublishing.org The role of gastrointestinal hormones in the regulation of appetite is reviewed. The gastrointestinal
tract is the largest endocrine organ in the body. Gut hormones function to optimize the process
of digestion and absorption of nutrients by the gut. In this capacity, their local effects on ... Cited by 43 - Related articles - BL Direct - All 12 versions
