- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
HS Kim, MS Lee - Cellular signalling, 2007 - Elsevier Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription
factors that mediate various biological responses, including cell proliferation, survival,
apoptosis, and differentiation. Among the members of the STAT family, accumulating ... Cited by 46 - Related articles - All 7 versions
- ►ahajournals.org C Vecchione, A Aretini, G Marino, U Bettarini, R … - Circulation …, 2006 - Am Heart Assoc Diabetes mellitus is a main risk factor for vascular diseases. Vascular injury induced by diabetes
mellitus is characterized by endothelial dysfunction attributable to an increased oxidative
stress. So far, the molecular mechanisms involved in the vasculotoxic effects of diabetes ... Cited by 24 - Related articles - All 9 versions
EPK Mensah-Brown, A Shahin, M Al- … - European journal of …, 2006 - interscience.wiley.com IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune
inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of
streptozotocin (MLD-STZ; 4 × 40 mg/kg body weight) in male C57BL/6 mice to study the ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org M Fujita, X Zhu, K Sasaki, R Ueda, KL Low, … - The Journal of …, 2008 - Am Assoc Immnol A variety of cancers, including malignant gliomas, show aberrant activation of STAT3, which
plays a pivotal role in negative regulation of antitumor immunity. We hypothesized that inhibition
of STAT3 signals would improve the efficacy of T cell adoptive transfer therapy by reversal ... Cited by 19 - Related articles - All 2 versions
WD'Hertog, L Overbergh, K Lage, GB Ferreira, M Maris, … - Mol. Cell. Proteomics, 2007 - ASBMB Proteomic analysis of cytokine-induced dysfunction and death in insulin ... D'Hertog W.1,*, Overbergh
L.1,*, Lage K.2, Ferreira GB1, Maris M.1 , Gysemans C.1, Flamez ... D.3, Cardozo AK3, Van den
Bergh G.4, Schoofs L.5,6, Arckens L.4,6, Moreau Y.8, Hansen Cited by 15 - Related articles - BL Direct - All 5 versions
AK Cardozo, V Buchillier, M Mathieu, J Chen, F Ortis, L … - BBA-Biomembranes, 2007 - Elsevier We have explored the threshold of tolerance of three unrelated cell types to treatments with potential
cytoprotective peptides bound to Tat 48–57 and Antp 43–58 cell-permeable peptide carriers.
Both Tat 48–57 and Antp 43–58 are well known for their good efficacy at crossing ... Cited by 13 - Related articles - All 3 versions
AM Barral, HE Thomas, EM Ling, R Darwiche, E … - Journal of Autoimmunity, 2006 - Elsevier CD8 + cytotoxic T lymphocytes (CTL) can rapidly kill β-cells and therefore contribute to the development
of type 1 diabetes (T1D). CTL-mediated β-cell killing can occur via perforin-mediated lysis,
Fas–Fas-L interaction, and the secretion of TNF-α or IFN-γ. The secretion of IFN-γ can ... Cited by 15 - Related articles - All 4 versions
- ►diabetesjournals.org HI Callewaert, CA Gysemans, L Ladrière, W D'Hertog, J … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Exposure of β-cells to inflammatory cytokines leads to apoptotic cell death through
the activation of gene networks under the control of specific transcription factors, such as
interferon-γ–induced signal transducer and activator of transcription (STAT)-1. We ... Cited by 14 - Related articles - BL Direct - All 6 versions
P Pirot, AK Cardozo, DL Eizirik - Arquivos Brasileiros de Endocrinologia & …, 2008 - SciELO Brasil Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from chronic
and progressive destruction of pancreatic beta-cells by the immune system. The triggering of
autoimmunity against the beta-cells is probably caused by environmental agent(s) acting ... Cited by 10 - Related articles - Cached - All 4 versions
