BR Henke, SM Sparks - Mini Reviews in Medicinal Chemistry, 2006 - ingentaconnect.com Metabolic and Viral Diseases Drug Discovery, GlaxoSmithKline, PO Box 13398, Research Triangle
Park, NC 27705, USA Abstract: Type 2 diabetes is a complex metabolic disease with hyperglycemia
as its recognizable hallmark. Hepatic glucose output is elevated in Type 2 diabetic ... Cited by 17 - Related articles - BL Direct - All 2 versions
DJ Baker, PL Greenhaff, A MacInnes, JA Timmons - Diabetes, 2006 - Am Diabetes Assoc Glycogen phosphorylase inhibition represents a promising strategy to suppress inappropriate
hepatic glucose output, while muscle glycogen is a major source of fuel during contraction. Glycogen
phosphorylase inhibitors (GPi) currently being investigated for the treatment of type 2 ... Cited by 10 - Related articles - BL Direct - All 7 versions
S Freeman, JB Bartlett, G Convey, I … - British journal of …, 2006 - pubmedcentral.nih.gov The activity of glycogen phosphorylase was modulated using the allosteric effectors glucose
or caffeine to promote the less active T state, and AMP to promote the more active R state. In
vitro potency of indole site inhibitors against liver and muscle glycogen phosphorylase a ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org DJ Baker, D Constantin-Teodosiu, SW Jones, JA … - Journal of Pharmacology …, 2006 - ASPET Decrements in skeletal muscle mass and functional capacity in response to cachexia, postoperative
inactivity, and sarcopenia (Busquets et al., 2004 Go ; Ryall et al., 2004 Go ) have a negative impact
on quality of life. The maintenance, or ideally, improvement of muscle strength and ... Cited by 5 - Related articles - BL Direct - All 5 versions
L Somsak, K Czifrak, M Toth, E Bokor, ED … - Current medicinal …, 2008 - ingentaconnect.com 1 Department of Organic Chemistry, University of Debrecen, POB 20, H-4010 Debrecen, Hungary
2 Institute of Organic & Pharmaceutical Chemistry, The National Hellenic Research
Foundation, 48 Vassileos Constan- tinou Avenue, GR-116 35, Athens, Greece Abstract: ... Cited by 3 - Related articles - All 3 versions
T Hadjiloi, C Tiraidis, ED Chrysina, DD Leonidas, … - Bioorganic & medicinal …, 2006 - Elsevier The catalytic site of GP has been extensively exploited for development of potent inhibitors of
the enzyme. [15] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30]
and [31] Sometime ago N-acetyl-β-d-glucopyranosylamine (6) was found to be a potent ... Cited by 1 - Related articles - All 5 versions
D Constantin-Teodosiu, DJ Baker, D … - The Journal of …, 2009 - Physiological Soc We have recently shown that PPAR agonism, used clinically to treat insulin resistance, increases
fat oxidation and up-regulates mitochondrial PDK4 mRNA and protein expression in resting skeletal
muscle. We hypothesized that PDK4 up-regulation, which inhibits pyruvate ... Cited by 1 - Related articles - All 5 versions
SM Poucher, S Freeman, SJG Loxham, G … - British Journal of …, 2007 - pubmedcentral.nih.gov In rat primary hepatocytes, GPi688 inhibited glucagons-mediated glucose output in a concentration
dependent manner. Additionally GP activity was reduced and GS activity increased
seven-fold. GPi688 inhibited glucagon-mediated hyperglycaemia in both Wistar (65%) & ... Cited by 1 - Related articles - BL Direct - All 3 versions
M Benltifa, S Vidal, B Fenet, M Msaddek, … - European Journal of …, 2006 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 1 - Related articles - BL Direct - All 2 versions
M Benltifa, JM Hayes, S Vidal, D Gueyrard, PG … - Bioorganic & Medicinal …, 2009 - Elsevier A series of glucopyranosylidene-spiro-isoxazolines was prepared through regio- and stereoselective
[3+2]-cycloaddition between the methylene acetylated exo-glucal and aromatic nitrile
oxides. The deprotected cycloadducts were evaluated as inhibitors of muscle glycogen ... Related articles
