- ►endojournals.org IS Farooqi, S O'Rahilly - Endocrine Reviews, 2006 - Endocrine Soc CHANGES IN DIET and physical activity have driven the rise in the prevalence of
adult and childhood obesity over a relatively short time interval (1, 2).
However, it is important to recognize the significant contribution of ... Cited by 89 - Related articles - BL Direct - All 4 versions
S Gesta, M Blüher, Y Yamamoto, AW Norris, J …, 2006 - National Acad Sciences Obesity, especially central obesity, is a hereditable trait associated with a
high risk for development of diabetes and metabolic disorders. Combined gene
expression analysis of adipocyte- and preadipocyte-containing fractions ... Cited by 77 - Related articles - BL Direct - All 12 versions
K Clément - Comptes rendus-Biologies, 2006 - Elsevier • several genetic variants interact with an 'at-risk' environment in common
obesities (polygenic obesities). Here each susceptibility gene, taken
individually, would only have a slight effect on weight. The cumulative ... Cited by 47 - Related articles - BL Direct - All 12 versions
DH Hall, T Rahman, PJ Avery, B Keavney - BMC medical genetics, 2006 - biomedcentral.com Obesity is a major public health problem. Body mass index (BMI) is a highly
heritable phenotype but robust associations of genetic polymorphisms to BMI or
other obesity-related phenotypes have been difficult to establish. Recently ... Cited by 38 - Related articles - Cached - All 11 versions
- ►nih.gov N Ahituv, N Kavaslar, W Schackwitz, A … - The American Journal of Human Genetics, 2007 - Elsevier Body weight is a quantitative trait with significant heritability in humans. To
identify potential genetic contributors to this phenotype, we resequenced the
coding exons and splice junctions of 58 genes in 379 obese and 378 lean ... Cited by 41 - Related articles - BL Direct - All 19 versions
- ►diabetesjournals.org IS Farooqi, S Drop, A Clements, JM Keogh, J … - Diabetes, 2006 - Am Diabetes Assoc Congenital deficiency of proopiomelanocortin (POMC) results in a syndrome of
hypoadrenalism, severe obesity, and altered skin and hair pigmentation. The
concept that subtle variation in POMC expression and/or function might ... Cited by 38 - Related articles - BL Direct - All 6 versions
JM Chen, C Ferec, DN Cooper - Human genetics, 2006 - Springer Abstract In an attempt both to catalogue 3¢ regulatory region (3¢ RR)-mediated
disease and to improve our understanding of the structure and function of the
3¢ RR, we have performed a systematic analysis of disease- associated ... Cited by 29 - Related articles - BL Direct - All 4 versions
JD Doecke, ZZ Zhao, MS Stark, AC Green, … - CANCER EPIDEMIOLOGY BIOMARKERS AND …, 2008 - AACR Rates of adenocarcinoma of the esophagus (EAC) and esophagogastric junction
(EGJAC) have been rising rapidly in recent decades, in contrast to the declining
rates of esophageal squamous cell carcinomas (ESCC). Obesity is a major ... Cited by 6 - Related articles - BL Direct - All 3 versions
C Lubrano, B Dubern, K Clément - Insights into Receptor Function and New Drug … - Springer Inrecentyears,themolecularapproachtohumanobesityhasadvancedtheunderstand- ing of
some causes and mechanisms of severe forms of obesity. Single rare mutations
largely contribute to the development of some obesity cases. Research was ... Cited by 1 - Related articles - All 2 versions
