CG Nichols - Nature, 2006 - nature.com Even in the absence of ATP, the single-channel kinetics of K ATP are complex,
but certain key features are clearly discernible and can be modelled by assuming
a single 'fast' gate and ligand-operated 'slow' gates within each subunit ... Cited by 136 - Related articles - BL Direct - All 8 versions
- ►shouxi.net ER Pearson, I Flechtner, PR Njolstad, MT … - New England Journal of Medicine, 2006 - content.nejm.org Background Heterozygous activating mutations in KCNJ11, encoding the Kir6.2
subunit of the ATP-sensitive potassium (K ATP ) channel, cause 30 to 58 percent
of cases of diabetes diagnosed in patients under six months of age. ... Cited by 127 - Related articles - BL Direct - All 13 versions
- ►oxfordjournals.org P Proks, AL Arnold, J Bruining, C Girard, SE … - Human molecular genetics, 2006 - Oxford Univ Press Neonatal diabetes is a genetically heterogeneous disorder with nine different
genetic aetiologies reported to date. Heterozygous activating mutations in the
KCNJ11 gene encoding Kir6.2, the pore-forming subunit of the ATP-sensitive ... Cited by 76 - Related articles - BL Direct - All 9 versions
SE Flanagan, EL Edghill, AL Gloyn, S Ellard, … - Diabetologia, 2006 - Springer Mutations in KCNJ11, which encodes Kir6.2, are a common cause ... Received: 3
November 2005 / Accepted: 28 February 2006 / Published online: 12 April 2006 #
Springer-Verlag 2006 ... Abstract Aims/hypothesis: Heterozygous ... Cited by 74 - Related articles - BL Direct - All 4 versions
- ►shouxi.net SE Flanagan, AM Patch, DJG Mackay, EL … - Diabetes, 2007 - Am Diabetes Assoc Transient neonatal diabetes mellitus (TNDM) is diagnosed in the first 6 months
of life, with remission in infancy or early childhood. For 50% of patients,
their diabetes will relapse in later life. The majority of cases result ... Cited by 50 - Related articles - BL Direct - All 8 versions
M Nishida, M Cadene, BT Chait, R … - The EMBO Journal, 2007 - pubmedcentral.nih.gov The Kir3.1 K channel participates in heart rate control and neuronal
excitability through G-protein and lipid signaling pathways. Expression in
Escherichia coli has been achieved by replacing three fourths of the ... Cited by 51 - Related articles - BL Direct - All 10 versions
- ►jbc.org N Baroukh, MA Ravier, MK Loder, EV Hill, A … - Journal of Biological Chemistry, 2007 - ASBMB MicroRNAs (miRNAs) are short non-coding RNAs that have been implicated in
fine-tuning gene regulation, although the precise roles of many are still
unknown. Pancreatic development is characterized by the complex sequential ... Cited by 52 - Related articles - All 7 versions
AT Hattersley, ER Pearson - Endocrinology, 2006 - Endocrine Soc Defining the molecular genetics of diabetes gives new insight into the
underlying etiology and so should help improve treatment. The genetic etiology
is now known for most patients with ß-cell monogenic diabetes, allowing ... Cited by 42 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org EL Edghill, RJ Dix, SE Flanagan, PJ Bingley, … - Diabetes, 2006 - Am Diabetes Assoc Children with permanent diabetes are usually assumed to have type 1 diabetes. It
has recently been shown that there are genetic subgroups of diabetes that are
often diagnosed during the neonatal period but may present later. A recent ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►physoc.org S Yamada, GC Kane, A Behfar, XK Liu, RB Dyer … - The Journal of physiology, 2006 - Physiological Soc Ventricular load can precipitate development of the heart failure syndrome, yet
the molecular components that control the cardiac adaptive response to imposed
demand remain partly understood. Compromised ATP-sensitive K + (K ATP ) ... Cited by 32 - Related articles - BL Direct - All 6 versions
