- ►nih.gov P Lefebvre, G Chinetti, JC Fruchart, B … - Journal of Clinical …, 2006 - Am Soc Clin Investig PPARα is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as well
as glucose homeostasis. Acting as a molecular sensor of endogenous fatty acids (FAs) and their
derivatives, this ligand-activated transcription factor regulates the expression of genes ... Cited by 210 - Related articles - BL Direct - All 9 versions
JN Feige, L Gelman, L Michalik, B Desvergne, W … - Progress in Lipid …, 2006 - Elsevier Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear receptors
which act as lipid sensors to modulate gene expression. As such, PPARs are implicated in major
metabolic and inflammatory regulations with far-reaching medical consequences, as well ... Cited by 158 - Related articles - All 2 versions
- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal
link between diabetes and diabetic complications. Four major molecular mechanisms have been
implicated in hyperglycemia-induced tissue damage: activation of protein kinase C (PKC) ... Cited by 120 - Related articles - All 7 versions
C Fiévet, JC Fruchart, B Staels - Current Opinion in Pharmacology, 2006 - Elsevier The discovery of the crucial role of peroxisome proliferator-activated receptors (PPARs) as regulators
of lipid and glucose metabolism has raised interest in the development of synthetic ligands as
potential tools for therapeutic intervention in type 2 diabetes and the metabolic syndrome. ... Cited by 56 - Related articles - All 2 versions
A Rubenstrunk, R Hanf, DW Hum, JC Fruchart, B … - BBA-Molecular and Cell …, 2007 - Elsevier Because of their wide range of actions on glucose homeostasis, lipid metabolism and vascular
inflammation, peroxisome proliferator-activated receptors (PPARs) are promising targets for the
development of new drugs for the treatment of metabolic disorders such as diabetes, ... Cited by 57 - Related articles - All 3 versions
- ►diabetesjournals.org SY Park, YR Cho, HJ Kim, T Higashimori, C Danton, … - Diabetes, 2005 - Am Diabetes Assoc Type 2 diabetes is a heterogeneous disease characterized by insulin resistance and altered
glucose and lipid metabolism in multiple organs. To understand the complex series of events
that occur during the development of obesity-associated diabetes, we examined the ... Cited by 53 - Related articles - BL Direct - All 6 versions
- ►nursing2008.com M Adiels, SO Olofsson, MR Taskinen, J … - Current opinion in …, 2006 - journals.lww.com Purpose of review Diabetic dyslipidaemia is a cluster of plasma lipid and lipoprotein abnormalities
that are metabolically interrelated. The increase of large type 1 very low density lipoprotein particles
in type 2 diabetes initiates a sequence of events that generates atherogenic remnants, ... Cited by 43 - Related articles - BL Direct - All 9 versions
- ►physiology.org S Boudina, ED Abel - Physiology, 2006 - Am Physiological Soc Diabetes is a worldwide epidemic (112). Cardiovascular disease remains the major cause of
morbidity and mortality in people with diabetes. Epidemiological studies suggest that the prevalence
of heart failure exceeds that which can be accounted for by other risk factors such as ... Cited by 39 - Related articles - BL Direct - All 5 versions
JJ Wu, RJ Roth, EJ Anderson, EG Hong, MK Lee, CS … - Cell metabolism, 2006 - Elsevier The mitogen-activated protein kinases (MAPK) play critical roles in the pathogenesis of diabetes
and obesity. The MAPKs are inactivated by MAPK phosphatases (MKPs) either in the cytosol
or nucleus. Here we show that mice lacking the nuclear-localized MKP, MKP-1 (mkp-1 −/− ... Cited by 38 - Related articles - All 11 versions
- ►cardiovascres.org BN Finck - Cardiovascular research, 2007 - cardiovascres.org Myocardial energy metabolism is an important determinant of cardiac structure and function.
Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac
disease. The peroxisome proliferator-activated receptor family (PPAR , β/ , ) of nuclear ... Cited by 36 - Related articles - All 8 versions
