LR Brunham, JK Kruit, TD Pape, JM Timmins, AQ … - Nature medicine, 2007 - nature.com Type 2 diabetes is characterized by both peripheral insulin resistance and reduced insulin secretion
by -cells. The reasons for -cell dysfunction in this disease are incompletely understood but may
include the accumulation of toxic lipids within this cell type. We examined the role of ... Cited by 44 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org JA Emamaullee, AM Shapiro - Diabetes, 2006 - Am Diabetes Assoc A substantial proportion of the transplanted islet mass fails to engraft due to death by
apoptosis, and a number of strategies have been explored to inhibit β-cell loss. Inhibition of extrinsic
signals of apoptosis (ie, cFLIP or A20) have been explored in experimental islet ... Cited by 31 - Related articles - BL Direct - All 10 versions
- ►asnjournals.org DA Thomas, C Stauffer, K Zhao, H Yang, VK … - Journal of the American …, 2007 - Am Soc Nephrol Apoptotic cell death is a defined pathway for islet cell demise, and mitochondrial dysfunction
contributes to islet cell apoptosis. The hypothesis that the novel peptide d-Arg-2',
6'-dimethyltyrosine-Lys-Phe-NH 2 (SS-31), previously shown to target inner mitochondrial ... Cited by 9 - Related articles - BL Direct - All 5 versions
JA Emamaullee, AMJ Shapiro, RV Rajotte, G Korbutt, … - Transplantation, 2006 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Cited by 4 - Related articles - BL Direct - All 3 versions
N Fiaschi-Taesch, AF Stewart, A Garcia-Ocana - Cell biochemistry and …, 2007 - Springer Abstract Clinical studies have demonstrated that islet transplantation may be a useful procedure
to replace beta cell function in patients with Type 1 diabetes. Islet trans- plantation faces many
challenges, including complications associated with the procedure itself, the toxicity of ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JD Rivas-Carrillo, A Soto-Gutierrez, N Navarro-Alvarez, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—V5 treatment upregulated expression of anti-apoptotic proteins Bcl-2 and XIAP
(X-linked inhibitor of apoptosis protein) by more than 3- and 11-fold and downregulated expression
of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB–p65 by 10, 30, and nearly ... Cited by 2 - Related articles - BL Direct - All 8 versions
S Londrigan, J Brady, R Sutherland, W … - …, 2007 - interscience.wiley.com Abstract: There is considerable interest in the viral modification of insulin-producing islets, including
porcine islets, in the context of islet xenotransplantation to treat type 1 diabetes. Adenovirus
(Adv) gene delivery offers the potential to modify pre-transplant islets for enhanced ... Cited by 2 - Related articles - BL Direct - All 3 versions
HE Thomas, MD McKenzie, E Angstetra, PD Campbell, … - Apoptosis - Springer Abstract Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss
of islets after trans- plantation. In type 1 diabetes, beta cells are destroyed by immunological
mechanisms. In type 2 diabetes abnormal levels of metabolic factors contribute to beta ... Cited by 2 - Related articles - All 2 versions
- ►endocrinology-journals.org G Harb, GS Korbutt - Journal of Endocrinology, 2006 - Soc Endocrinology Prolonged exposure to high glucose can influence the function, growth, and survival of pancreatic
ß-cells. In this study, we examine the effects of prolonged in vitro exposure to high glucose on
neonatal porcine ß-cells, a potentially useful source of insulin-producing cells for clinical ... Cited by 1 - Related articles - BL Direct - All 4 versions
