S Merani, A Shapiro - Clinical Science, 2006 - submit.clinsci.org Abbreviations: BMI, body mass index; CD40L, CD40 ligand; CITR, Collaborative
Islet Transplant Registry; CTLA4, cytotoxic T-lymphocyte attenuator protein 4;
CMV, cytomegalovirus; DCCT, Diabetes Control and Complications Trial; DM, ... Cited by 40 - Related articles - Cached - BL Direct - All 12 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JA Emamaullee, AM Shapiro - Diabetes, 2006 - Am Diabetes Assoc A substantial proportion of the transplanted islet mass fails to engraft due to
death by apoptosis, and a number of strategies have been explored to inhibit
β-cell loss. Inhibition of extrinsic signals of apoptosis (ie, cFLIP or ... Cited by 31 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org JA Emamaullee, L Stanton, C Schur, AM … - Diabetes, 2007 - Am Diabetes Assoc Islet transplantation can provide insulin independence in patients with type 1
diabetes, but islets derived from two or more donors are often required. A
significant fraction of the functional islet mass is lost to apoptosis in ... Cited by 21 - Related articles - BL Direct - All 5 versions
D vanderwindt, R Bottino, A Casu, N … - Xenotransplantation, 2007 - interscience.wiley.com Abstract: Islets isolated from multiple pancreas donors are often necessary to
achieve euglycemia in type 1 diabetic patients treated by islet
allotransplantation. This increases the burden on the limited pool of donor ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org MD McKenzie, EM Carrington, T Kaufmann, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Development and function of islets were not affected by loss of Bid,
and Bid-deficient islets were as susceptible as wild-type islets to cytotoxic
stimuli that cause apoptosis via the mitochondrial pathway. In contrast, ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►physiology.org G Path, A Opel, M Gehlen, V Rothhammer, X … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc TO DATE, IT IS CONTROVERSIAL whether neogenesis from pancreatic precursor cells
present in ducts (2) and islets of Langerhans (45) or self duplication of
existing -cells (12) contributes to the formation of new pancreatic -cells ... Cited by 9 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org DA Thomas, C Stauffer, K Zhao, H Yang, VK … - Journal of the American Society of Nephrology, 2007 - Am Soc Nephrol Apoptotic cell death is a defined pathway for islet cell demise, and
mitochondrial dysfunction contributes to islet cell apoptosis. The hypothesis
that the novel peptide d-Arg-2', 6'-dimethyltyrosine-Lys-Phe-NH 2 (SS-31), ... Cited by 7 - Related articles - BL Direct - All 5 versions
JA Emamaullee, J Davis, R Pawlick, C Toso, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Clinical islet transplantation can provide insulin independence in
patients with type 1 diabetes, but chronic graft failure has been observed. This
has been attributed in part to loss of ≥60% of the transplanted islets in ... Cited by 5 - Related articles - All 4 versions
- ►endojournals.org S Merani, W Truong, JA Emamaullee, C Toso … - Endocrinology, 2008 - Endocrine Soc The current scarcity of high-quality deceased pancreas donors prevents
widespread application of islet transplantation for treatment of labile type 1
diabetes mellitus. Opportunities for the improvement of current techniques ... Cited by 5 - Related articles - All 4 versions
