- ►nih.gov [PDF] KS Lang, P Georgiev, M Recher, AA … - Journal of Clinical …, 2006 - Am Soc Clin Investig The liver is known to be a classical immunoprivileged site with a relatively high resistance against
immune responses. Here we demonstrate that highly activated liver-specific effector CD8 + T
cells alone were not sufficient to trigger immune destruction of the liver in mice. Only ... Cited by 61 - Related articles - BL Direct - All 11 versions
KS Lang, A Burow, M Kurrer, PA Lang, M Recher - Journal of Autoimmunity, 2007 - Elsevier Autoimmune diseases are the clinical correlate of a dysregulation of the immune system, involving
multiple steps and multiple components of both the innate and the adaptive immune system.
Innate immune cells are sensitive to a very limited repertoire of foreign “patterns” that bind ... Cited by 46 - Related articles - All 3 versions
- ►nih.gov E Vercammen, J Staal, R Beyaert - Clinical Microbiology Reviews, 2008 - cmr.highwire.org Toll-like receptors (TLRs) form a major group of transmembrane receptors that are involved in
the detection of invading pathogens. Double-stranded RNA is a marker for viral infection that
is recognized by TLR3. TLR3 triggering activates specific signaling pathways that ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] M Colonna - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Many autoimmune diseases are thought to be precipitated by viral infections. In this issue of
the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections
not only trigger expansion of self-reactive T cells but also activate antigen-presenting ... Cited by 18 - Related articles - BL Direct - All 10 versions
- ►uva.nl [PDF] TC Schreuder, HC Gelderblom, CJ Weegink, D … - Liver International, 2008 - medscape.com We screened for DM during and after treatment with pegylated-IFN-α (Peg-IFN-α) and Riba for
chronic HCV infection. This started after we observed two index cases of DM during
Peg-IFN-α/Riba treatment in our hospital in December 2002. In the first patient, ... Cited by 8 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org [PDF] Z Dogusan, M García, D Flamez, L Alexopoulou, M … - Diabetes, 2008 - Am Diabetes Assoc 1 Laboratory of Experimental Medicine, Université Libre de Bruxelles, Brussels, Belgium. 2 Centre
d'Immunologie de Marseille-Luminy, CNRS-INSERM- Université de la Mediterranée,
Marseille, France. 3 Institute of Medical Immunology, Université Libre de Bruxelles, ... Cited by 9 - Related articles - All 2 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong inflammatory
component. The latest studies indicate that innate immunity and inflammatory mediators have
a much broader role in T1DM than initially assumed. Inflammation might contribute to ... Cited by 8 - Related articles - All 8 versions
E Lien, D Zipris - Current Molecular Medicine, 2009 - ingentaconnect.com 1 Department of Medicine, University of Massachusetts Medical School, Worcester, MA
01655, USA 2 Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University
of Colorado, Aurora, CO 80045, USA Abstract: Toll-like receptors (TLRs) and the innate ... Cited by 5 - Related articles - All 2 versions
D Zipris - Current Opinion in Endocrinology, Diabetes and …, 2008 - journals.lww.com Purpose of review: Over the last 2 decades, studies addressing mechanisms of type 1 diabetes
have focused primarily on the role of T lymphocytes in disease mechanisms. Recent
investigations, however, suggest that the innate immune system plays a key role in ... Cited by 4 - Related articles - All 3 versions
- ►diabetesjournals.org Z Dogusan, M García, D Flamez, L Alexopoulou, M … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Viral infections contribute to the pathogenesis of type 1 diabetes. Viruses, or viral
products such as double-stranded RNA (dsRNA), affect pancreatic β-cell survival and trigger
autoimmunity by unknown mechanisms. We presently investigated the mediators and ... Cited by 4 - Related articles - BL Direct - All 5 versions
