- ►nih.gov T Nir, DA Melton, Y Dor - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The mechanisms that regulate pancreatic β cell mass are poorly understood.
While autoimmune and pharmacological destruction of insulin-producing β cells
is often irreversible, adult β cell mass does fluctuate in response to ... Cited by 101 - Related articles - BL Direct - All 8 versions
- ►upenn.edu [PDF] M Teta, MM Rankin, SY Long, GM Stein, JA … - Developmental cell, 2007 - Elsevier Cellular progenitors remain poorly characterized in many adult tissues, limited
in part by the lack of unbiased techniques to identify progenitors and their
progeny. To address this fundamental problem, we developed a novel DNA ... Cited by 88 - Related articles - All 12 versions
K Brennand, D Huangfu, D Melton - PLoS Biol, 2007 - biology.plosjournals.org In healthy adult mice, the β cell population is not maintained by stem cells
but instead by the replication of differentiated β cells. It is not known,
however, whether all β cells contribute equally to growth and maintenance, ... Cited by 60 - Related articles - Cached - All 10 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
PC Butler, JJ Meier, AE Butler, A Bhushan - Nature clinical practice. Endocrinology & metabolism, 2007 - ncbi.nlm.nih.gov Replication of beta cells is an important source of beta-cell expansion in early
childhood. The recent linkage of type 2 diabetes with several transcription
factors involved in cell cycle regulation implies that growth of the ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►nih.gov BM Desai, J Oliver-Krasinski, DD De Leon, C … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig It has been suggested that pancreatic acinar cells can serve as progenitors for
pancreatic islets, a concept with substantial implications for therapeutic
efforts to increase insulin-producing β cell mass in patients with ... Cited by 41 - Related articles - BL Direct - All 7 versions
G Parnaud, D Bosco, T Berney, F Pattou, J … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis The aim of the study was to determine whether purified
beta cells can replicate in vitro and whether this is enhanced by extracellular
matrix (ECM) and growth factors. Methods Human beta cells were purified by ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►shouxi.net NA Sherry, JA Kushner, M Glandt, T Kitamura, … - Diabetes, 2006 - Am Diabetes Assoc In other clinical settings of increased metabolic needs, β-cell mass increases
in response to metabolic changes (3,4). Increased β-cell mass occurs when
insulin resistance causes increased demand for insulin secretion, after ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org AM Ackermann, M Gannon - Journal of molecular endocrinology, 2007 - Soc Endocrinology Pancreatic ß-cells are responsible for producing all of the insulin required by
an organism to maintain glucose homeostasis. Defects in development,
maintenance, or expansion of ß-cell mass can result in impaired glucose ... Cited by 35 - Related articles - All 4 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
