- ►biologists.org LC Murtaugh - Development, 2007 - dev.biologists.org The development of insulin-producing pancreatic beta (ß)-cells represents the culmination of
a complex developmental program. Cells of the posterior foregut assume a pancreatic
identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a ... Cited by 56 - Related articles - BL Direct - All 5 versions
JH Park, DA Stoffers, RD Nicholls, RA … - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Intrauterine growth retardation (IUGR) has been linked to the onset of diseases in adulthood,
including type 2 diabetes, and has been proposed to result from altered gene regulation patterns
due to epigenetic modifications of developmental genes. To determine whether ... Cited by 22 - Related articles - BL Direct - All 7 versions
JM Oliver-Krasinski, DA Stoffers - Genes & development, 2008 - genesdev.cshlp.org The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and decreased
β-cell numbers, raising hope for cell replacement therapy. Although human islet transplantation
is a cell-based therapy under clinical investigation for the treatment of type 1 diabetes, the ... Cited by 21 - Related articles - All 4 versions
- ►nih.gov DA Babu, TG Deering, RG Mirmira - Molecular genetics and metabolism, 2007 - Elsevier Emerging evidence over the past decade indicates a central role for transcription factors in the
embryonic development of pancreatic islets and the consequent maintenance of normal glucose
homeostasis. Pancreatic and duodenal homeobox 1 (Pdx1) is the best studied and ... Cited by 17 - Related articles - All 3 versions
TG Fellous, NJ Guppy, M Brittan, MR … - Diabetes/Metabolism … - interscience.wiley.com In the twenty-first century, diabetic patients are likely to be one of the major beneficiaries from
the advancement of regenerative medicine through cellular therapies. Though the existence
of a specific self-renewing stem cell within the pancreas is still far from clear, a surprising ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DA Cano, IC Rulifson, PW Heiser, LB Swigart, S … - Diabetes, 2008 - Am Diabetes Assoc Several studies have shown that the adult pancreas possesses a limited potential for β-cell regeneration
upon tissue injury. One of the difficulties in studying β-cell regeneration has been the lack of
a robust, synchronized animal model system that would allow controlled regulation of ... Cited by 15 - Related articles - BL Direct - All 3 versions
DA Cano, M Hebrok, M Zenker - Gastroenterology, 2007 - Elsevier The last decade has seen tremendous advances in understanding the molecular mechanisms
that control vertebrate organogenesis. Transgenic animal models, mainly in mouse and
zebrafish, have allowed the mapping of endodermal cell specification toward pancreas ... Cited by 14 - Related articles - All 21 versions
DM Keller, S McWeeney, A Arsenlis, J Drouin, CVE … - Journal of Biological …, 2007 - ASBMB The homeobox transcription factor Pdx-1 is necessary for pancreas organogenesis and beta
cell function, however, most Pdx-1-regulated genes are unknown. To further the understanding
of Pdx-1 in beta cell biology, we have characterized its genomic targets in NIT-1 cells, a ... Cited by 16 - Related articles - All 5 versions
- ►physiology.org DD De Leon, C Farzad, MF Crutchlow, J … - Physiological …, 2006 - Am Physiological Soc After partial pancreatectomy (Ppx), substantial regeneration of the endocrine and exocrine pancreatic
compartments has been shown in adult rodents. Exendin-4 (Ex-4) is a glucagon-like
peptide-1 receptor agonist that augments endocrine ß-cell mass by stimulating ... Cited by 13 - Related articles - BL Direct - All 3 versions
- ►jbc.org TB Deramaudt, MM Sachdeva, MP Wescott, Y Chen … - Journal of Biological …, 2006 - ASBMB Keratin 19 is a member of the cytokeratin family that is critical for maintenance of cellular architecture
and organization, especially of epithelia. The pancreas has three distinct cell types, ductal,
acinar, and islet, each with different functions. Embryologically, the pancreatic and ... Cited by 11 - Related articles - All 6 versions
