Y Cai, GA Martens, SA Hinke, H Heimberg, D … - Free Radical Biology and Medicine, 2007 - Elsevier AMP-activated protein kinase influences cellular metabolism, glucose-regulated
gene expression, and insulin secretion of pancreatic beta cells. Its sustained
activation by culture at low glucose concentrations or in the presence of 5- ... Cited by 22 - Related articles - All 5 versions
WH Kim, JW Lee, YH Suh, HJ Lee, SH Lee, … - Cellular signalling, 2007 - Elsevier We previously demonstrated that chronic high glucose (33.3 mM) induced β-cell
dysfunction and apoptosis through glucokinase (GCK) downregulation, but the
exact mechanisms involved remain unclear. Here, we show that prolonged ... Cited by 21 - Related articles - All 5 versions
- ►shouxi.net PJ Jensen, JD Gitlin, MO Carayannopoulos - Journal of Biological Chemistry, 2006 - ASBMB GLUT1 is essential for human brain development and function, as evidenced by the
severe epileptic encephalopathy observed in children with GLUT1 deficiency
syndrome resulting from inherited loss-of-function mutations in the gene ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►pnas.org Y Emre, C Hurtaud, M Karaca, T Nubel, F … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Infiltration of inflammatory cells into pancreatic islets of Langerhans and
selective destruction of insulin-secreting β-cells are characteristics of type
1 diabetes. Uncoupling protein 2 (UCP2) is a mitochondrial protein ... Cited by 18 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org JD Wikstrom, SM Katzman, H Mohamed, G Twig, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—β-Cell response to glucose is characterized by mitochondrial
membrane potential (ΔΨ) hyperpolarization and the production of metabolites
that serve as insulin secretory signals. We have previously shown that ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org JE Bruin, HC Gerstein, KM Morrison, AC … - Toxicological sciences, 2008 - Soc Toxicology In Canada, nicotine replacement therapy is recommended as a safe smoking
cessation aid for pregnant women. However, we have shown in an animal model that
fetal and neonatal nicotine exposure causes increased beta-cell apoptosis ... Cited by 9 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Baltrusch, M Tiedge - Diabetes, 2006 - Am Diabetes Assoc The low-affinity glucose-phosphorylating enzyme glucokinase (GK) is the
flux-limiting glucose sensor in liver and β-cells of the pancreas. Furthermore,
GK is also expressed in various neuroendocrine cell types. This review ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►endojournals.org X Huang, DJ Moore, RJ Ketchum, CS … - Endocrine Reviews, 2008 - Endocrine Soc Although type 1 diabetes cannot be prevented or reversed, replacement of insulin
production by transplantation of the pancreas or pancreatic islets represents a
definitive solution. At present, transplantation can restore euglycemia, ... Cited by 5 - Related articles - All 4 versions
B Kuklinski, C Philipp - Praxis, 2007 - omundernaehrung.com Gerade Letzterer reagiert vulnerabel auf nitrosativen Stress, insbesondere der
Pyruvatdehydrogenasekom- plex und die Aconitase. Laktaterhöhungen können, aber
brauchen nicht auftreten. Isolierte pathologisch hohe ... Cited by 9 - Related articles - All 21 versions
MK Joe, HJ Lee, YH Suh, KL Han, JH Lim, J … - Cellular signalling, 2008 - Elsevier Neuronatin (Nnat) was initially identified as a selectively-expressed gene in
neonatal brains, but its expression has been also identified in pancreatic
β-cells. Therefore, to investigate the possible functions that Nnat may ... Cited by 4 - Related articles - All 7 versions
