- ►nih.gov TB Huber, C Kwoh, H Wu, K Asanuma, M … - Journal of Clinical …, 2006 - Am Soc Clin Investig Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular diagnosis
resulting in end-stage renal disease. Defects in several podocyte proteins have been implicated
in the etiology of FSGS, including podocin, α-actinin–4, CD2-associated protein (CD2AP), ... Cited by 47 - Related articles - BL Direct - All 11 versions
- ►amjpathol.org DW Wong, GY Oudit, H Reich, Z Kassiri, J Zhou, QC … - American Journal of …, 2007 - ASIP Activation of the renin-angiotensin system (RAS) and the generation of angiotensin (Ang) II play
an important role in the pathogenesis of diabetic nephropathy and blockade of the RAS in both
experimental and clinical diabetes mellitus attenuates the development of diabetic kidney ... Cited by 37 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org D Westermann, S Rutschow, S Jäger, A Linderer, S … - Diabetes, 2007 - Am Diabetes Assoc We investigated the effect of the angiotensin type 1 (AT-1) receptor antagonist, irbesartan, on
matrix metalloproteinase (MMP) activity and cardiac cytokines in an animal model of diabetic
cardiomyopathy. Diabetes was induced in 20 C57/bl6 mice by injection of streptozotocin ( ... Cited by 31 - Related articles - BL Direct - All 7 versions
- ►endojournals.org C Guo, D Martinez-Vasquez, GP Mendez, MF Toniolo, … - Endocrinology, 2006 - Endocrine Soc To determine whether mineralocorticoid receptor (MR) activation plays a role in diabetic renal
injury and whether this role differs in types 1 and 2 diabetes mellitus, we examined the effect
of a MR antagonist on renal injury in rodent models of type 1 (streptozotocin-treated rat) ... Cited by 32 - Related articles - BL Direct - All 4 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human population. Like
humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains
differ in the response of their critical physiological functions, such as insulin sensitivity, ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►nih.gov AB Fogo - Pediatric Nephrology, 2007 - Springer Abstract Chronic kidney disease (CKD) occurs in all age groups, including children. Regardless
of the underlying cause, CKD is characterized by progressive scarring that ultimately affects all
structures of the kidney. The relentless progression of CKD is postulated to result from a ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org K van de Wetering, N Zelcer, A Kuil, W Feddema, M … - Molecular pharmacology, 2007 - ASPET Glucuronidation is a major hepatic detoxification pathway for endogenous and exogenous
compounds, resulting in the intracellular formation of polar metabolites that require specialized
transporters for elimination. Multidrug resistance proteins (MRPs) are expressed in the ... Cited by 26 - Related articles - All 6 versions
- ►amjpathol.org Y Kanetsuna, K Takahashi, M Nagata, MA Gannon, … - American Journal of …, 2007 - ASIP Recent studies have implicated dysfunctional endothelial nitric-oxide synthase (eNOS) as a common
pathogenic pathway in diabetic vascular complications. However, functional consequences are
still incompletely understood. To determine the role of eNOS-derived nitric oxide (NO) in ... Cited by 17 - Related articles - BL Direct - All 9 versions
Z Zhang, Y Zhang, G Ning, DK Deb, J Kong, … - Proceedings of the …, 2008 - vietwebdisk.com The renin–angiotensin system (RAS) plays a critical role in the development of diabetic
nephropathy, and blockade of the RAS is currently used for treatment of diabetic
nephropathy. One major problem for the current RAS inhibitors is the compensatory renin ... Cited by 14 - Related articles - All 11 versions
- ►amjpathol.org KJ Williams, G Qiu, HK Usui, SR Dunn, P McCue, E … - American Journal of …, 2007 - ASIP The small leucine-rich proteoglycan decorin has been implicated in the regulation of collagen
fibril assembly, cell adhesion, and growth factor activity. 6-8 For several reasons, we sought to
examine a role for decorin in diabetic nephropathy. First, decorin is an endogenous ... Cited by 16 - Related articles - BL Direct - All 6 versions
