- ►endojournals.org KE Foster-Schubert, DE Cummings - Endocrine reviews, 2006 - Endocrine Soc The rising tide of obesity is one of the most pressing health issues of our time, yet existing medicines
to combat the problem are disappointingly limited in number and effectiveness. Fortunately, a
recent burgeoning of mechanistic insights into the neuroendocrine regulation of body ... Cited by 36 - Related articles - BL Direct - All 8 versions
AM Brennan, CS Mantzoros - Nature Reviews Endocrinology, 2006 - nature.com Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis. Studies in animal
models, in humans with congenital complete leptin deficiency, and observational and interventional
studies in humans with relative leptin deficiency (lower than normal leptin levels) have all ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►auburn.edu [PDF] YX Tao - Pharmacology and Therapeutics, 2006 - Elsevier Since the discovery of the first rhodopsin mutation that causes retinitis pigmentosa in 1990, significant
progresses have been made in elucidating the pathophysiology of diseases caused by inactivating
mutations of G protein-coupled receptors (GPCRs). This review aims to compile the ... Cited by 33 - Related articles - All 7 versions
- ►endojournals.org GM Sutton, JL Trevaskis, MW Hulver, RP McMillan, NJ … - Endocrinology, 2006 - Endocrine Soc Loss of brain melanocortin receptors (Mc3rKO and Mc4rKO) causes increased adiposity and
exacerbates diet-induced obesity (DIO). Little is known about how Mc3r or Mc4r genotype,
diet, and obesity affect insulin sensitivity. Insulin resistance, assessed by insulin and ... Cited by 29 - Related articles - BL Direct - All 6 versions
DM Mutch, K Clément - Best Practice & Research Clinical Endocrinology & …, 2006 - Elsevier This chapter presents the current state of knowledge in the field of the genetics of human
obesity. The molecular approach has proved to be powerful in defining new syndromes associated
with obesity. The pivotal role of leptin and melanocortin pathways has been recognized, ... Cited by 22 - Related articles - All 8 versions
- ►ajcn.org N Santoro, L Perrone, G Cirillo, P Raimondo, … - American Journal of …, 2007 - Am Soc Nutrition Background:The central melanocortin system is critical for the long-term regulation of energy
homeostasis. Melanocortin-3 receptor (MC3R) knock-out mice, despite being hypophagic, have
increased fat mass and higher feed efficiency than do their wild-type littermates. Cited by 20 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org S Lee… - Diabetes, 2007 - Am Diabetes Assoc RESULTS—In vitro functional studies of the resultant mutant receptors revealed impaired signaling
activity but normal ligand binding and cell surface expression. The heterozygotes demonstrated
higher leptin levels and adiposity and less hunger compared with obese control subjects, ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►endojournals.org YC Tung, SJ Piper, D Yeung, S O'Rahilly, AP Coll - Endocrinology, 2006 - Endocrine Soc Functional disruption of either MC3R or MC4R results in obesity, implicating both in the control
of energy homeostasis. The ligands for these receptors are derived from the prohormone proopiomelancortin
(POMC), which is posttranslationally processed to produce a set of melanocortin peptides ... Cited by 10 - Related articles - BL Direct - All 3 versions
M Lee, SL Wardlaw - Front Biosci, 2007 - bioscience.org The central melanocortin system is comprised of discrete populations of neurons and circuits
that play a key role in maintaining energy balance. This system can sense levels of peripheral
energy stores and can integrate a variety of nutrient, neuronal and hormonal signals to ... Cited by 5 - Related articles - View as HTML - All 2 versions
