- ►diabetesjournals.org K Morino, KF Petersen, GI Shulman - Diabetes, 2006 - Am Diabetes Assoc Recent studies using magnetic resonance spectroscopy have shown that decreased
insulin-stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport
activity is a major factor in the pathogenesis of type 2 diabetes. The molecular mechanism ... Cited by 125 - Related articles - BL Direct - All 5 versions
R Marone, V Cmiljanovic, B Giese, MP Wymann - BBA-Proteins and Proteomics, 2008 - Elsevier Phosphoinositide 3-kinases (PI3K) orchestrate cell responses including mitogenic signaling,
cell survival and growth, metabolic control, vesicular trafficking, degranulation, cytoskeletal rearrangement
and migration. Deregulation of the PI3K pathway occurs by activating mutations in growth ... Cited by 82 - Related articles - All 2 versions
B Draznin - Diabetes, 2006 - Am Diabetes Assoc Initial attempts to unravel the molecular mechanism of insulin resistance have strongly suggested
that a defect responsible for insulin resistance in the majority of patients lies at the postreceptor
level of insulin signaling. Subsequent studies in insulin-resistant animal models and ... Cited by 51 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] HH Zhang, AI Lipovsky, CC Dibble, M Sahin, BD … - Molecular cell, 2006 - Elsevier Feedback inhibition of the PI3K-Akt pathway by the mammalian target of rapamycin complex
1 (mTORC1) has emerged as an important signaling event in tumor syndromes, cancer, and
insulin resistance. Cells lacking the tuberous sclerosis complex (TSC) gene products are ... Cited by 49 - Related articles - All 12 versions
M Roden - International Journal of Obesity, 2005 - nature.com REL-DM exhibit defects in mitochondrial oxidation and phosphorylation. Increased FFA availability
results in accumulation of intramyocellular fatty acyl-CoA (FA-CoA) inducing a series of
alterations: (i) inhibition of insulin signaling, (ii) reduction of insulin-(in)dependent glucose ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►nih.gov P Gulati, LD Gaspers, SG Dann, M Joaquin, T … - Cell metabolism, 2008 - Elsevier Excess levels of circulating amino acids (AAs) play a causal role in specific human
pathologies, including obesity and type 2 diabetes. Moreover, obesity and diabetes are contributing
factors in the development of cancer, with recent studies suggesting that this link is ... Cited by 39 - Related articles - All 9 versions
- ►cell.com N Luong, CR Davies, RJ Wessells, SM Graham, MT … - Cell metabolism, 2006 - Elsevier Reducing insulin/IGF signaling allows for organismal survival during periods of inhospitable
conditions by regulating the diapause state, whereby the organism stockpiles lipids, reduces
fertility, increases stress resistance, and has an increased lifespan. The Target of ... Cited by 32 - Related articles - All 13 versions
- ►diabetesjournals.org M Krebs, B Brunmair, A Brehm, M Artwohl, J … - Diabetes, 2007 - Am Diabetes Assoc Type 2 diabetes is closely linked to obesity and insulin resistance (1–3). In addition to polygenic
predisposition, environmental factors including quality and quantity of food supply, dietary
behavior, and physical activity are of major importance for the development of type 2 ... Cited by 26 - Related articles - BL Direct - All 5 versions
F Tremblay, S Brûlé, S Hee Um, Y Li, K … - Proceedings of the …, 2007 - National Acad Sciences S6K1 has emerged as a critical signaling component in the development of insulin resistance
through phosphorylation and inhibition of IRS-1 function. This effect can be triggered directly
by nutrients such as amino acids or by insulin through a homeostatic negative-feedback ... Cited by 23 - Related articles - BL Direct - All 5 versions
EM Rzucidlo, KA Martin, RJ Powell - Journal of Vascular Surgery, 2007 - Elsevier Vascular smooth muscle cell (VSMC) differentiation is an essential component of vascular
development. These cells perform biosynthetic, proliferative, and contractile roles in the vessel
wall. VSMCs are not terminally differentiated and are able to modulate their phenotype in ... Cited by 21 - Related articles - All 35 versions
