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Scholar Results 1 - 10 of about 41 citing Bach: Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle. (0.10 sec) 

Mitochondria: more than just a powerhouse

- cell.com
HM McBride, M Neuspiel, S Wasiak - Current Biology, 2006 - Elsevier
Pioneering biochemical studies have long forged the concept that the mitochondria are the 'energy
powerhouse of the cell'. These studies, combined with the unique evolutionary origin of the
mitochondria, led the way to decades of research focusing on the organelle as an ...
Cited by 129 - Related articles - All 10 versions

Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome …

- diabetesjournals.org
FX Soriano, M Liesa, D Bach, DC Chan, M Palacín, A … - Diabetes, 2006 - Am Diabetes Assoc
Mitofusin 2 (Mfn2) is a mitochondrial membrane protein that participates in mitochondrial fusion
and regulates mitochondrial metabolism in mammalian cells. Here, we show that Mfn2 gene
expression is induced in skeletal muscle and brown adipose tissue by conditions ...
Cited by 36 - Related articles - BL Direct - All 4 versions

Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin …

- oxfordjournals.org
KW Chung, SB Kim, KD Park, KG Choi, JH Lee, HW … - Brain, 2006 - Oxford Univ Press
Mutations in the mitofusin 2 (MFN2) gene, which encodes a mitochondrial GTPase mitofusin
protein, have recently been reported to cause both Charcot–Marie–Tooth 2A (CMT2A) and hereditary
motor and sensory neuropathy VI (HMSN VI). It is well known that HMSN VI is an axonal ...
Cited by 38 - Related articles - BL Direct - All 6 versions

Mechanisms of disease: mitochondria as new therapeutic targets in diabetic …


GM Leinninger, JL Edwards, MJ Lipshaw, EL … - Nature Clinical Practice …, 2006 - nature.com
Eva L Feldman received her MD and Ph.D. in Neuroscience at the University of Michigan, Ann
Arbor, MI, USA and completed her residency in Neurology at the Johns Hopkins Hospital,
Baltimore, PA, USA. She returned to the University of Michigan, where she is the Russell ...
Cited by 27 - Related articles - BL Direct - All 3 versions

Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim …

- du.edu [PDF] 
GM Leinninger, C Backus, AM Sastry, YB Yi, CW … - Neurobiology of disease, 2006 - Elsevier
Dorsal root ganglia (DRG) neurons degenerate in diabetic neuropathy (DN) and exhibit mitochondrial
damage. We studied mitochondria of cultured DRG neurons exposed to high glucose as an in
vitro model of DN. High glucose sequentially increases the expression, activation and ...
Cited by 18 - Related articles - All 7 versions

Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A disease


PD Dominique Loiseau, A Chevrollier, C Verny, V … - Annals of … - interscience.wiley.com
It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...
Cited by 14 - Related articles - BL Direct - All 3 versions

PGC-1 {alpha}'s relationship with skeletal muscle palmitate oxidation is not present …

- physiology.org
GP Holloway, CGR Perry, A Thrush, GJF … - American Journal of …, 2008 - Am Physiological Soc
Reduced skeletal muscle mitochondrial content and fatty acid oxidation are associated with obesity
and insulin resistance. Although the exact mechanisms remain elusive, this may result from impaired
mitochondrial biogenesis or reductions in the mitochondrial reticulum network. Therefore, ...
Cited by 10 - Related articles - All 3 versions

Pyridine nucleotide redox abnormalities in diabetes


Y Ido - Antioxidants & Redox Signaling, 2007 - liebertonline.com
C HEMICAL REACTIONS involving movement of electrons are called redox reactions (reduction
and oxidation). This review will describe characteristics of redox abnormali- ties observed in
diabetes. Diabetes affects a number of tissues and organs including liver, micro- and ...
Cited by 11 - Related articles - BL Direct - All 5 versions

Mitofusin 2 (Mfn2): a key player in insulin-dependent myogenesis in vitro


P Pawlikowska, B Gajkowska, A Orzechowski - Cell and Tissue Research, 2007 - Springer
Abstract We have previously shown that mitochondrial activity increases in response to insulin
in differentiating muscle cells. Moreover, the protein kinase kinase/extracel- lular-signal-regulated
kinase (MAPKK/ERK-MEK) inhibi- tor PD98059 accelerates insulin-mediated ...
Cited by 9 - Related articles - BL Direct - All 3 versions

Upregulation of peroxisome proliferator-activated receptor gamma coactivator …


G Gastaldi, A Russell, A Golay, JP Giacobino, F … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis We investigated whether skeletal muscle per- oxisome
proliferator-activated receptor gamma coactivator-1 (PGC1A; also known as PPARGC1A) and
its target mitofusin-2 (MFN2), as well as carnitine palmitoyltransferase-1 (CPT1; also ...
Cited by 7 - Related articles - BL Direct - All 2 versions


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