- ►nas.edu [PDF] JP Mordes, P Poussier, AR Rossini, EP … - Animal Models of … - books.google.com 2 Animal Models of Diabetes BBDR Rats and Translational Modeling Fidelity 19 Immunological
Perturbation and Diabetes Induction in Other Rat Strains 20 TLRLigation 20 Viral Infection 21
A Working Hypothesis of Autoimmune Diabetes in the Rat 21 What Does Autoimmune ... Cited by 43 - Related articles - BL Direct - All 4 versions
N van der Werf, FG Kroese, J Rozing, JL … - Diabetes/Metabolism … - interscience.wiley.com During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly, reaching
percentages of 3% annually worldwide. This increase suggests that besides genetical factors
environmental perturbations (including viral infections) are also involved in the ... Cited by 39 - Related articles - BL Direct - All 3 versions
BO ROEP - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2007 - interscience.wiley.com Abstract : Despite decades of research using various animal models for type 1 diabetes, we are
still struggling to define the initiating autoantigens, the precise mechanisms of β cell
destruction, and suitable immune-based interventions to prevent or treat human diabetes. ... Cited by 9 - Related articles - BL Direct - All 5 versions
E Lien, D Zipris - Current Molecular Medicine, 2009 - ingentaconnect.com 1 Department of Medicine, University of Massachusetts Medical School, Worcester, MA
01655, USA 2 Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University
of Colorado, Aurora, CO 80045, USA Abstract: Toll-like receptors (TLRs) and the innate ... Cited by 5 - Related articles - All 2 versions
JP Mordes, L Cort, E Norowski, J Leif, JM Fuller, Å … - Mammalian Genome, 2009 - Springer Abstract Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated with autoimmune
diabetes. Its effects have been well-documented in BB-derived rats in which diabetes is either
induced by immunologic perturba- tion or occurs spontaneously. The role of Iddm14 in ... Cited by 4 - Related articles - All 2 versions
A Agua-Doce, L Graca - … IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA …, 2007 - Springer Summary Monoclonal antibodies (MAb) have been shown to be effective in inducing immune
tolerance in transplantation and autoimmunity. Several different MAb have tolerogenic properties
and their effect has been studied in a range of experimental animal models and, in some ... Cited by 1 - Related articles - BL Direct - All 4 versions
D Zipris - Clinical Immunology, 2009 - Elsevier There is a consensus among epidemiologists that the worldwide incidence rate of type 1 diabetes
has been rising in recent decades. The cause of this rise is unknown, but epidemiological studies
suggest the involvement of environmental factors, and viral infections in particular. Data ... Cited by 1 - Related articles - All 2 versions
P Chopra… - In vivo (Athens, Greece), 2009 - pubmedcentral.nih.gov Invariant natural killer T (iNKT) cells are a subset of T cells that express both T cell receptor
(TCR) molecules and specific NK cell receptors [1–4]. The TCR alpha and beta chains expressed
by iNKT cells do not undergo random variable region recombination [4,5]; their invariant ... Related articles - All 4 versions
J Unadkat, M Feili-Hariri - Expert Opin. Drug Discov., 2008 - informahealthcare.com Background: Dendritic cells (DC) have the unique ability to induce immunity against tumors and
various pathogens or to promote tolerance in autoimmunity and transplantation. Hence, they
are central to the regulation of immune responses. Objective/methods: Due to the unique ... Related articles - All 4 versions