- ►diabetesjournals.org L Shu, NS Sauter, FT Schulthess, AV … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—To investigate the effects of TCFL7L2 depletion,
isolated islets were exposed to TCF7L2 small interfering RNA (siRNA) versus
scrambled siRNA, and β-cell survival and function were examined. For ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DJ Michael, RA Ritzel, L Haataja, RH Chow - Diabetes, 2006 - Am Diabetes Assoc Insulin vesicles contain a chemically rich mixture of cargo that includes ions,
small molecules, and proteins. At present, it is unclear if all components of
this cargo escape from the vesicle at the same rate or to the same extent ... Cited by 23 - Related articles - BL Direct - All 6 versions
JJ Meier, MA Nauck - Current Diabetes Reports, 2006 - Springer The incretin hormones gastric inhibitory polypeptide (GIP) and glucagon-like
peptide 1 (GLP-1) are released in response to nutrient ingestion and potentiate
glucose- stimulated insulin secretion from pancreatic β cells. The ... Cited by 20 - Related articles - BL Direct - All 2 versions
- ►shouxi.net EP Kwan, L Xie, L Sheu, T Ohtsuka, HY … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—To determine which exocytotic steps caused by Munc13-1 deficiency are
rescued by Epac2 and PKA, we used patch-clamp capacitance measurements, showing
that 1) cAMP restored the reduced readily releasable pool (RRP) and ... Cited by 16 - Related articles - BL Direct - All 4 versions
PE MacDonald, P Rorsman - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is
crucial to maintenance of plasma glucose levels. They fuse with the plasma
membrane in a regulated manner to release their contents and are ... Cited by 13 - Related articles - BL Direct - All 4 versions
S Marcelli-Tourvieille, T Hubert, F Pattou, … - Diabetes and Metabolism, 2006 - Elsevier Various stimuli have been used in clinical practice to test islet function,
including intravenous glucose, arginine — both at basal glucose levels and
with the hyperglycaemic clamp, tolbutamide, glucagon and glucagon-like ... Cited by 6 - Related articles - BL Direct - All 3 versions
LR Ranganath - Clinical Chemistry and Laboratory Medicine, 2007 - reference-global.com Incretins such as glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide 1 (GLP-1) are intestinal hormones that are released in
response to ingestion of nutrients, especially carbohydrate. They have a ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►physiology.org GA Rutter, EV Hill - Physiology, 2006 - Am Physiological Soc The mechanisms by which insulin-containing dense core secretory vesicles
approach and finally fuse with the plasma membrane are of considerable current
interest: defects in these processes may be one of the contributing factors ... Cited by 6 - Related articles - BL Direct - All 4 versions
NE Mikhail - Endocrine Practice, 2006 - AACE Defective insulin secretion and insulin resistance con- tribute independently to
the development of type 2 dia- betes (1). In addition, type 2 diabetes is
generally charac- terized by inappropriately elevated plasma fasting and ... Cited by 6 - Related articles - BL Direct - All 2 versions
