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Scholar Results 1 - 10 of about 28 citing Kjørholt: Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the.... (0.08 sec) 

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

- pubget.com [PDF] 
DR Laybutt, AM Preston, MC Åkerfeldt, JG Kench, AK … - Diabetologia, 2007 - Springer
Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & JG Kench & AK Busch
& AV Biankin & TJ Biden Received: 21 September 2006 ...
Cited by 105 - Related articles - BL Direct - All 5 versions

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia

- shouxi.net
G Xu, H Kaneto, DR Laybutt, VF Duvivier-Kali, N Trivedi … - Diabetes, 2007 - Am Diabetes Assoc
Stimulation of insulin secretion by the incretin hormones glucagon-like peptide 1 (GLP-1) and
glucose-dependent insulinotropic peptide (GIP) has been found to be diminished in type 2
diabetes. We hypothesized that this impairment is due to a defect at the receptor level ...
Cited by 26 - Related articles - BL Direct - All 5 versions

Endogenous islet uncoupling protein-2 expression and loss of glucose …

- endocrinology-journals.org
MC Saleh, MB Wheeler, CB Chan - Journal of Endocrinology, 2006 - Soc Endocrinology
We hypothesized that the loss of glucose homeostasis in ob/ob mice is associated with upregulation
of islet uncoupling protein-2 (UCP2) expression, leading to impaired glucose-stimulated insulin
secretion (GSIS). Changes in glucose homeostasis in lean and ob/ob mice from 5 to 16 ...
Cited by 18 - Related articles - BL Direct - All 3 versions

[PDF] Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: …


YIH Sakamoto, SMK Kawakami, TMK … - Biochemical and …, 2006 - genome.tokushima-u.ac.jp
The GPR119 was recently shown to be activated by oleoylethanolamide (OEA), a naturally occurring
bioactive lipid with hypophagic and anti-obesity effects. In this study, we have cloned and characterized
its murine counterpart, Gpr119. The full-length cDNA contained an open reading frame of ...
Cited by 17 - Related articles - View as HTML - All 4 versions

Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion …


A Wiederkehr, CB Wollheim - Cell Calcium, 2008 - Elsevier
Mitochondria play an essential role in metabolism-secretion coupling in the pancreatic
β-cell. Dysfunction of the organelle leads to impaired glucose-stimulated insulin secretion, as
exemplified by the rare disease mitochondrial diabetes, which is caused by mutations in ...
Cited by 16 - Related articles - All 3 versions

Influence of diabetes on the loss of beta cell differentiation after islet transplantation …

- pubget.com [PDF] 
DR Laybutt, YC Hawkins, J Lock, J Lebet, A Sharma, S … - Diabetologia, 2007 - Springer
Page 1. ARTICLE Influence of diabetes on the loss of beta cell differentiation after islet
transplantation in rats DR Laybutt & YC Hawkins & J. Lock & J. Lebet & A. Sharma &
S. Bonner-Weir & GC Weir Received: 7 May 2007 /Accepted ...
Cited by 10 - Related articles - BL Direct - All 4 versions

Cytokine-induced {beta}-cell death is independent of endoplasmic reticulum stress …

- diabetesjournals.org
MC Akerfeldt, J Howes, JY Chan, VA Stevens, N … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—Cytokines and palmitate triggered ER stress in β-cells as evidenced by increased
phosphorylation of PKR-like ER kinase (PERK), eukaryotic initiation factor (EIF)2α, and Jun NH
2 -terminal kinase (JNK) and increased expression of activating transcription factor ...
Cited by 9 - Related articles - All 3 versions

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β- …


P Lovis, E Roggli, DR Laybutt, S Gattesco, JY Yang, C … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—Prolonged exposure of the β-cell line MIN6B1 and pancreatic islets to palmitate
causes a time- and dose-dependent increase of miR34a and miR146. Elevated levels of these
miRNAs are also observed in islets of diabetic db/db mice. miR34a rise is linked to ...
Cited by 8 - Related articles - All 4 versions

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured …


J Shoda, K Okada, Y Inada, H Kusama, H … - Hepatology …, 2007 - interscience.wiley.com
Aim and Methods: A decreased function of multidrug-resistance 3 P-glycoprotein (MDR3), limiting
the rate of biliary phospholipid secretion, predisposes individuals to cholestasis and/or
cholangitis. Fibrates induce the expression of mdr2 (homolog of human MDR3) in ...
Cited by 6 - Related articles - All 2 versions

Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine …


S Nakano, T Nagasawa, T Ijiro, Y Inada, T Tamura, … - Hepatol Res, 2008 - interscience.wiley.com
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Cited by 5 - Related articles - All 3 versions


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