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Scholar Results 1 - 10 of about 26 citing Prudente: The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated.... (0.10 sec) 

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

- salk.edu [PDF] 
L Qi, JE Heredia, JY Altarejos, R Screaton, … - Science's STKE, 2006 - stke.sciencemag.org
Abstract: During fasting, increased concentrations of circulating catecholamines
promote the mobilization of lipid stores from adipose tissue in part by
phosphorylating and inactivating acetyl–coenzyme A carboxylase (ACC), the ...
Cited by 55 - Related articles - BL Direct - All 15 versions

The role of intracellular signaling in insulin-mediated regulation of drug metabolizing …

- nih.gov
SK Kim, RF Novak - Pharmacology and Therapeutics, 2007 - Elsevier
Endogenous factors, including hormones, growth factors and cytokines, play an
important role in the regulation of hepatic drug metabolizing enzyme expression
in both physiological and pathophysiological conditions. Diabetes, fasting, ...
Cited by 33 - Related articles - All 4 versions

Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity

- jbc.org
R Matsushima, N Harada, NJG Webster, YM … - Journal of Biological Chemistry, 2006 - ASBMB
Insulin and nutrients activate hepatic p70 S6 kinase (S6K1) to regulate protein
synthesis. Paradoxically, activation of S6K1 also leads to the development of
insulin resistance. In this study, we investigated the effect of TRB3, ...
Cited by 29 - Related articles - All 7 versions

TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative …

- jbc.org
C Jousse, C Deval, AC Maurin, L Parry, Y … - Journal of Biological Chemistry, 2007 - ASBMB
The integrated stress response (ISR) is defined as a highly conserved response
to several stresses that converge to the induction of the activating
transcription factor 4 (ATF4). Because an uncontrolled response may have ...
Cited by 27 - Related articles - All 7 versions

TRB3 modulates C2C12 differentiation by interfering with Akt activation


S Kato, K Du - Biochemical and Biophysical Research …, 2007 - Elsevier
TRB3 is a member of TRB protein family characterized by containing a variant
kinase domain without enzymatic activity. Interacting with Ser/Thr protein
kinases Akt, TRB3 impairs Akt activation induced by growth factors and ...
Cited by 19 - Related articles - All 5 versions

ENPP1 gene, insulin resistance and related clinical outcomes


S Bacci, S De Cosmo, S Prudente, V Trischitta - Current Opinion in Clinical Nutrition & Metabolic Care, 2007 - journals.lww.com
Purpose of review: Insulin resistance plays a significant role in both morbidity
and mortality of the general population. Understanding the molecular mechanisms
of insulin resistance would help the identification of at-risk individuals ...
Cited by 10 - Related articles - BL Direct - All 4 versions

TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in …

- ahajournals.org
F Andreozzi, G Formoso, S Prudente, ML Hribal, … - Arteriosclerosis, thrombosis, and vascular biology, 2008 - Am Heart Assoc
From the Department of Experimental and Clinical Medicine (FA, MLH, GS),
University Magna Græcia of Catanzaro, Catanzaro, Italy; Department of Medicine
and Aging Sciences (GF, AC), University "G. d'Annunzio", Aging Research ...
Cited by 6 - Related articles - All 8 versions

PI3K activates negative and positive signals to regulate TRB3 expression in hepatic cells


J Ding, S Kato, K Du - Experimental Cell Research, 2008 - Elsevier
TRB3 is a pseudokinase whose expression is regulated during stress response and
changing of nutrient status. TRB3 negatively regulates Akt activation and
noticeably, TRB3 expression is induced by insulin. Here, we sought to ...
Cited by 5 - Related articles - All 3 versions

Dietary fat, genes and insulin sensitivity

- ciberobn.es [PDF] 
J López-Miranda, P Pérez-Martínez, C Marin, … - Journal of Molecular Medicine, 2007 - Springer
Abstract Both insulin resistance and dyslipidaemia are determined by genetic and
environmental factors. Depending on their expression and their function, gene
variants may influence either insulin action or dyslipidaemia. The purpose ...
Cited by 4 - Related articles - BL Direct - All 6 versions

The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes


S Prudente, D Scarpelli, M Chandalia, YY Zhang … - Journal of Clinical Endocrinology & Metabolism, 2009 - Endocrine Soc
Context: The prevalence of type 2 diabetes (T2D), particularly among young
adults, has been rising steadily during the past 2 decades. T2D, especially in
its early-onset subtype, is under genetic control. TRIB3 inhibits insulin- ...
Cited by 3 - Related articles - All 4 versions


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